Literature DB >> 22318157

Design, synthesis, single-crystal and preliminary antitumor activity of novel arenesulfonylimidazolidin-2-ones.

Alaa A-M Abdel-Aziz1, Adel S El-Azab, Hussein I El-Subbagh, Abdulrahman M Al-Obaid, Amer M Alanazi, Mohamed A Al-Omar.   

Abstract

Novel series of 1-(arenesulfonyl)imidazolidin-2-one (3a-i) and 1,3-bis(arenesulfonyl)imidazolidin-2-one (5a-i) have been synthesized and tested for their antitumor activity against 60 tumor cell lines taken from nine different organs. A significant inhibition for cancer cells was observed with series 5a-i compounds compared with the series 3a-i which showed a weak inhibition. Compounds 5a-i showed good inhibitory effect at the lung cancer HOP-92 and renal cancer CAKI-1 and UO-31 cell lines. Compound 5e showed remarkable broad-spectrum antitumor activity.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22318157     DOI： 10.1016/j.bmcl.2012.01.036

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Synthesis and In Vitro Antimicrobial Evaluation of New 1,3,4-Oxadiazoles Bearing 5-Chloro-2-methoxyphenyl Moiety.

Authors:  Basavapatna N Prasanna Kumar; Kikkeri N Mohana; Lingappa Mallesha; Kikkeri P Harish
Journal:  Int J Med Chem       Date:  2013-03-31

2.  Synthesis, antitumour activities and molecular docking of thiocarboxylic acid ester-based NSAID scaffolds: COX-2 inhibition and mechanistic studies.

Authors:  Adel S El-Azab; Alaa A-M Abdel-Aziz; Laila A Abou-Zeid; Walaa M El-Husseiny; Ahmad M El Morsy; Manal A El-Gendy; Magda A-A El-Sayed
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

3.  Fluoroenesulphonamides: N-sulphonylurea isosteres showing nanomolar selective cancer-related transmembrane human carbonic anhydrase inhibition.

Authors:  Benoit Métayer; Andrea Angeli; Agnès Mingot; Kévin Jouvin; Gwilherm Evano; Claudiu T Supuran; Sébastien Thibaudeau
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

4.  Synthesis and biological evaluation of 2-styrylquinolines as antitumour agents and EGFR kinase inhibitors: molecular docking study.

Authors:  Magda A-A El-Sayed; Walaa M El-Husseiny; Naglaa I Abdel-Aziz; Adel S El-Azab; Hatem A Abuelizz; Alaa A-M Abdel-Aziz
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

5.  Exploring structure-activity relationship of S-substituted 2-mercaptoquinazolin-4(3H)-one including 4-ethylbenzenesulfonamides as human carbonic anhydrase inhibitors.

Authors:  Adel S El-Azab; Alaa A-M Abdel-Aziz; Hany E A Ahmed; Sivia Bua; Alessio Nocentini; Nawaf A AlSaif; Ahmad J Obaidullah; Mohamed M Hefnawy; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051

6.  Synthesis, anti-inflammatory, cytotoxic, and COX-1/2 inhibitory activities of cyclic imides bearing 3-benzenesulfonamide, oxime, and β-phenylalanine scaffolds: a molecular docking study.

Authors:  Alaa A-M Abdel-Aziz; Adel S El-Azab; Nawaf A AlSaif; Mohammed M Alanazi; Manal A El-Gendy; Ahmad J Obaidullah; Hamad M Alkahtani; Abdulrahman A Almehizia; Ibrahim A Al-Suwaidan
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051

7.  Synthesis, potential antitumor activity, cell cycle analysis, and multitarget mechanisms of novel hydrazones incorporating a 4-methylsulfonylbenzene scaffold: a molecular docking study.

Authors:  Alaa A-M Abdel-Aziz; Adel S El-Azab; Nawaf A AlSaif; Ahmad J Obaidullah; Abdulrahman M Al-Obaid; Ibrahim A Al-Suwaidan
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

8.  Synthesis, antitumour and antioxidant activities of novel α,β-unsaturated ketones and related heterocyclic analogues: EGFR inhibition and molecular modelling study.

Authors:  Walaa M El-Husseiny; Magda A-A El-Sayed; Naglaa I Abdel-Aziz; Adel S El-Azab; Esam R Ahmed; Alaa A-M Abdel-Aziz
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

9.  Synthesis, antitumor activity, and molecular docking study of 2-cyclopentyloxyanisole derivatives: mechanistic study of enzyme inhibition.

Authors:  Walaa M El-Husseiny; Magda A-A El-Sayed; Adel S El-Azab; Nawaf A AlSaif; Mohammed M Alanazi; Alaa A-M Abdel-Aziz
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051

10.  S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors.

Authors:  Adel S El-Azab; Alaa A-M Abdel-Aziz; Silvia Bua; Alessio Nocentini; Nawaf A AlSaif; Mohammed M Alanazi; Manal A El-Gendy; Hany E A Ahmed; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051
  10 in total

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