Literature DB >> 2231692

Gag precursors of HIV and SIV are cleaved into six proteins found in the mature virions.

L E Henderson1, R C Sowder, T D Copeland, S Oroszlan, R E Benveniste.   

Abstract

During retroviral maturation gag precursors are proteolytically cleaved to mature gag proteins. The number of mature gag proteins and their order in the gag precursors of HIV-I3B, SIVMne (captive macaque isolate), and SIVCat (wild mangabey isolate) has been determined by N-terminal amino acid sequence analysis of mature gag proteins and alignment with predicted sequences of homologous gag precursors. For HIV-1 and SIVs maturation proteolysis results in six gag proteins and the gag precursor cleavage pattern is distinctive and different from cleavage patterns for all other known retroviruses.

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Year:  1990        PMID： 2231692

Source DB:  PubMed          Journal:  J Med Primatol        ISSN： 0047-2565            Impact factor:   0.667


  23 in total

1.  Membrane association induces a conformational change in the Ebola virus matrix protein.

Authors:  S Scianimanico; G Schoehn; J Timmins; R H Ruigrok; H D Klenk; W Weissenhorn
Journal:  EMBO J       Date:  2000-12-15       Impact factor: 11.598

2.  The dimer interfaces of protease and extra-protease domains influence the activation of protease and the specificity of GagPol cleavage.

Authors:  Steven C Pettit; Sergei Gulnik; Lori Everitt; Andrew H Kaplan
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103

3.  Determinants of the human immunodeficiency virus type 1 p15NC-RNA interaction that affect enhanced cleavage by the viral protease.

Authors:  N Sheng; S C Pettit; R J Tritch; D H Ozturk; M M Rayner; R Swanstrom; S Erickson-Viitanen
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

4.  Gag proteins of the highly replicative MN strain of human immunodeficiency virus type 1: posttranslational modifications, proteolytic processings, and complete amino acid sequences.

Authors:  L E Henderson; M A Bowers; R C Sowder; S A Serabyn; D G Johnson; J W Bess; L O Arthur; D K Bryant; C Fenselau
Journal:  J Virol       Date:  1992-04       Impact factor: 5.103

5.  Phosphorylation and proteolytic cleavage of gag proteins in budded simian immunodeficiency virus.

Authors:  Sarah M Rue; Jason W Roos; Patrick M Tarwater; Janice E Clements; Sheila A Barber
Journal:  J Virol       Date:  2005-02       Impact factor: 5.103

6.  Roles of the human immunodeficiency virus type 1 nucleocapsid protein in annealing and initiation versus elongation in reverse transcription of viral negative-strand strong-stop DNA.

Authors:  L Rong; C Liang; M Hsu; L Kleiman; P Petitjean; H de Rocquigny; B P Roques; M A Wainberg
Journal:  J Virol       Date:  1998-11       Impact factor: 5.103

Review 7.  The gag proteins of human immunodeficiency virus type 1: mechanisms of virus assembly and possibilities for interference.

Authors:  S Modrow; B Kattenbeck; A von Poblotzki; M Niedrig; R Wagner; H Wolf
Journal:  Med Microbiol Immunol       Date:  1994-09       Impact factor: 3.402

8.  Characterization of a putative alpha-helix across the capsid-SP1 boundary that is critical for the multimerization of human immunodeficiency virus type 1 gag.

Authors:  Chen Liang; Jing Hu; Rodney S Russell; Ariel Roldan; Lawrence Kleiman; Mark A Wainberg
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

9.  Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease.

Authors:  Steve C Pettit; Gavin J Henderson; Celia A Schiffer; Ronald Swanstrom
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103

10.  Detection of human immunodeficiency virus type 1 nucleocapsid protein p7 in vitro and in vivo.

Authors:  M P de Baar; K H van der Horn; J Goudsmit; A de Ronde; F de Wolf
Journal:  J Clin Microbiol       Date:  1999-01       Impact factor: 5.948
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