| Literature DB >> 2231684 |
D C Montefiori1, W E Robinson, V M Hirsch, A Modliszewski, W M Mitchell, P R Johnson.
Abstract
Plasma from four rhesus macaques (Macaca mulatta), of which two were experimentally infected with the simian immunodeficiency virus (SIV) isolate SIVmac251, one with isolate SIVsmF236, and another with a SIVsmF236 molecular clone, SIVsmH-4, enhanced SIVmac infection of MT-2 cells. In addition to SIV-positive plasma, infection-enhancement required complement, CD4, and CR2. Titers of infection-enhancing antibodies appeared to correlate with disease progression. The MT-2/SIVmac251 system should be useful in future studies of complement-mediated, antibody-dependent enhancement of macaque and sooty mangabey SIV isolates.Entities:
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Year: 1990 PMID： 2231684
Source DB: PubMed Journal: J Med Primatol ISSN： 0047-2565 Impact factor: 0.667