| Literature DB >> 22316669 |
Tanya R Flohr1, Hugo Bonatti, Tjasa Hranjec, Doug S Keith, Peter I Lobo, Sean C Kumer, Timothy M Schmitt, Robert G Sawyer, Timothy L Pruett, John P Roberts, Kenneth L Brayman.
Abstract
Our institution explored using allografts from donors with Hepatitis C virus (HCV) for elderly renal transplantation (RT). Thirteen HCV- elderly recipients were transplanted with HCV+ allografts (eD+/R-) between January 2003 and April 2009. Ninety HCV- elderly recipients of HCV- allografts (eD-/R-), eight HCV+ recipients of HCV+ allografts (D+/R+) and thirteen HCV+ recipients of HCV- allografts (D-/R+) were also transplanted. Median follow-up was 1.5 (range 0.8-5) years. Seven eD+/R- developed a positive HCV viral load and six had elevated liver transaminases with evidence of hepatitis on biopsy. Overall, eD+/R- survival was 46% while the eD-/R- survival was 85% (P = 0.003). Seven eD+/R- died during follow-up. Causes included multi-organ failure and sepsis (n = 4), cancer (n = 1), failure-to-thrive (n = 1) and surgical complications (n = 1). One eD+/R- died from causes directly related to HCV infection. In conclusion, multiple eD+/R- quickly developed HCV-related liver disease and infections were a frequent cause of morbidity and mortality.Entities:
Mesh：
Substances：
Year: 2011 PMID： 22316669 PMCID： PMC3401245 DOI： 10.1016/j.jss.2011.10.028
Source DB: PubMed Journal: J Surg Res ISSN： 0022-4804 Impact factor: 2.192