Literature DB >> 22314535

Expression turnover profiling to monitor the antifungal activities of amphotericin B, voriconazole, and micafungin against Aspergillus fumigatus.

Yanan Zhao1, Padmaja Paderu, Steven Park, Aleksandra Dukhan, Meredith Senter, David S Perlin.   

Abstract

Eight highly expressed candidate genes were selected for mRNA profiling to monitor the transcriptome kinetics of Aspergillus fumigatus strains exposed to antifungal drugs as potential biomarkers of live cells to assess treatment efficacy. Mycelia were treated with fungicidal drugs amphotericin B and voriconazole, as well as the fungistatic drug micafungin. Transcription was monitored at 0, 4, 8, and 24 h posttreatment. The expression turnover profile provides a possible tool to assess antifungal therapy effects.

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Year:  2012        PMID： 22314535      PMCID： PMC3346633          DOI： 10.1128/AAC.06163-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

Authors:  K J Livak; T D Schmittgen
Journal:  Methods       Date:  2001-12       Impact factor: 3.608

Review 2.  Characterization of Aspergillus fumigatus mutants with reduced susceptibility to caspofungin.

Authors:  R E Gardiner; P Souteropoulos; S Park; D S Perlin
Journal:  Med Mycol       Date:  2005-05       Impact factor: 4.076

3.  Aspergillus PCR: one step closer to standardization.

Authors:  P Lewis White; Stéphane Bretagne; Lena Klingspor; Willem J G Melchers; Elaine McCulloch; Bettina Schulz; Niklas Finnstrom; Carlo Mengoli; Rosemary A Barnes; J Peter Donnelly; Juergen Loeffler
Journal:  J Clin Microbiol       Date:  2010-02-10       Impact factor: 5.948

4.  Method for measuring postantifungal effect in Aspergillus species.

Authors:  Roxana G Vitale; Johan W Mouton; Javier Afeltra; Jacques F G M Meis; Paul E Verweij
Journal:  Antimicrob Agents Chemother       Date:  2002-06       Impact factor: 5.191

5.  Aspergillus infection in lung transplant patients: incidence and prognosis.

Authors:  M Iversen; C M Burton; S Vand; L Skovfoged; J Carlsen; N Milman; C B Andersen; M Rasmussen; M Tvede
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2007-12       Impact factor: 3.267

6.  A comparative study of the post-antifungal effect (PAFE) of amphotericin B, triazoles and echinocandins on Aspergillus fumigatus and Candida albicans.

Authors:  Elias K Manavathu; Mayur S Ramesh; Inthumathi Baskaran; Latha T Ganesan; Pranatharthi H Chandrasekar
Journal:  J Antimicrob Chemother       Date:  2004-01-16       Impact factor: 5.790

7.  Post-antifungal effect of amphotericin B and voriconazole against germinated Aspergillus fumigatus conidia.

Authors:  Erja Chryssanthou; Alissha Loebig; Jan Sjölin
Journal:  J Antimicrob Chemother       Date:  2008-03-26       Impact factor: 5.790

8.  Fungal infections in recipients of hematopoietic stem cell transplants: results of the SEIFEM B-2004 study--Sorveglianza Epidemiologica Infezioni Fungine Nelle Emopatie Maligne.

Authors:  L Pagano; M Caira; A Nosari; M T Van Lint; A Candoni; M Offidani; T Aloisi; G Irrera; A Bonini; M Picardi; C Caramatti; R Invernizzi; D Mattei; L Melillo; C de Waure; G Reddiconto; L Fianchi; C G Valentini; C Girmenia; G Leone; F Aversa
Journal:  Clin Infect Dis       Date:  2007-09-26       Impact factor: 9.079

9.  Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors.

Authors:  Kieren A Marr; Rachel A Carter; Michael Boeckh; Paul Martin; Lawrence Corey
Journal:  Blood       Date:  2002-08-22       Impact factor: 22.113

Review 10.  Invasive aspergillosis: epidemiology, diagnosis and management in immunocompromised patients.

Authors:  Georg Maschmeyer; Antje Haas; Oliver A Cornely
Journal:  Drugs       Date:  2007       Impact factor: 11.431
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  3 in total

1.  Antifungal drug testing by combining minimal inhibitory concentration testing with target identification by gas chromatography-mass spectrometry.

Authors:  Christoph Müller; Ulrike Binder; Franz Bracher; Martin Giera
Journal:  Nat Protoc       Date:  2017-04-06       Impact factor: 13.491

2.  Tailoring amphotericin B as an ionic liquid: an upfront strategy to potentiate the biological activity of antifungal drugs.

Authors:  Diego O Hartmann; Karina Shimizu; Maika Rothkegel; Marija Petkovic; Ricardo Ferraz; Željko Petrovski; Luís C Branco; José N Canongia Lopes; Cristina Silva Pereira
Journal:  RSC Adv       Date:  2021-04-16       Impact factor: 3.361

3.  Transcriptomics Analysis of the Chinese Pear Pathotype of Alternaria alternata Gives Insights into Novel Mechanisms of HSAF Antifungal Activities.

Authors:  Feng He; Bingxin Li; Gan Ai; Alex Machio Kange; Yancun Zhao; Xiong Zhang; Yifan Jia; Daolong Dou; Fengquan Liu; Haiqun Cao
Journal:  Int J Mol Sci       Date:  2018-06-22       Impact factor: 5.923
  3 in total

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