Literature DB >> 22314529

blaNDM-1 is a chimera likely constructed in Acinetobacter baumannii.

M A Toleman1, J Spencer, L Jones, T R Walsh.   

Abstract

Alignment of DNA sequences found upstream of aphA6 and all bla(NDM-1) genes displays 100% identity. This identity continues 19 bp into the bla(NDM-1) gene such that the first 6 amino acids of aphA6 and bla(NDM-1) are the same. Furthermore, the percent GC content (GC%) of aphA6 is considerably lower than that of bla(NDM-1) and the GC% within the bla(NDM-1) structural gene changes dramatically after the first 19 bp. This is unequivocal evidence that bla(NDM-1) is a chimera.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22314529      PMCID： PMC3346620          DOI： 10.1128/AAC.06297-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

1.  ISCR elements are key players in IncA/C plasmid evolution.

Authors:  Mark A Toleman; Timothy R Walsh
Journal:  Antimicrob Agents Chemother       Date:  2010-08       Impact factor: 5.191

Review 2.  ISCR elements: novel gene-capturing systems of the 21st century?

Authors:  Mark A Toleman; Peter M Bennett; Timothy R Walsh
Journal:  Microbiol Mol Biol Rev       Date:  2006-06       Impact factor: 11.056

3.  Evolution of the ISCR3 group of ISCR elements.

Authors:  Mark A Toleman; Timothy R Walsh
Journal:  Antimicrob Agents Chemother       Date:  2008-07-28       Impact factor: 5.191

4.  The new medical challenge: why NDM-1? Why Indian?

Authors:  Timothy R Walsh; Mark A Toleman
Journal:  Expert Rev Anti Infect Ther       Date:  2011-02       Impact factor: 5.091

5.  Dissemination of amikacin resistance gene aphA6 in Acinetobacter spp.

Authors:  T Lambert; G Gerbaud; P Bouvet; J F Vieu; P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  1990-06       Impact factor: 5.191

6.  Nucleotide sequence of Acinetobacter baumannii aphA-6 gene: evolutionary and functional implications of sequence homologies with nucleotide-binding proteins, kinases and other aminoglycoside-modifying enzymes.

Authors:  P Martin; E Jullien; P Courvalin
Journal:  Mol Microbiol       Date:  1988-09       Impact factor: 3.501

7.  Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study.

Authors:  Timothy R Walsh; Janis Weeks; David M Livermore; Mark A Toleman
Journal:  Lancet Infect Dis       Date:  2011-04-07       Impact factor: 25.071

8.  Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India.

Authors:  Dongeun Yong; Mark A Toleman; Christian G Giske; Hyun S Cho; Kristina Sundman; Kyungwon Lee; Timothy R Walsh
Journal:  Antimicrob Agents Chemother       Date:  2009-09-21       Impact factor: 5.191

9.  Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study.

Authors:  Karthikeyan K Kumarasamy; Mark A Toleman; Timothy R Walsh; Jay Bagaria; Fafhana Butt; Ravikumar Balakrishnan; Uma Chaudhary; Michel Doumith; Christian G Giske; Seema Irfan; Padma Krishnan; Anil V Kumar; Sunil Maharjan; Shazad Mushtaq; Tabassum Noorie; David L Paterson; Andrew Pearson; Claire Perry; Rachel Pike; Bhargavi Rao; Ujjwayini Ray; Jayanta B Sarma; Madhu Sharma; Elizabeth Sheridan; Mandayam A Thirunarayan; Jane Turton; Supriya Upadhyay; Marina Warner; William Welfare; David M Livermore; Neil Woodford
Journal:  Lancet Infect Dis       Date:  2010-08-10       Impact factor: 25.071

Review 10.  Has the era of untreatable infections arrived?

Authors:  David M Livermore
Journal:  J Antimicrob Chemother       Date:  2009-09       Impact factor: 5.790
View more
  48 in total

1.  The first NDM metallo-β-lactamase-producing Enterobacteriaceae isolate in Poland: evolution of IncFII-type plasmids carrying the bla(NDM-1) gene.

Authors:  J Fiett; A Baraniak; R Izdebski; I Sitkiewicz; D Żabicka; A Meler; K Filczak; W Hryniewicz; M Gniadkowski
Journal:  Antimicrob Agents Chemother       Date:  2013-11-18       Impact factor: 5.191

Review 2.  Mobile Genetic Elements Associated with Antimicrobial Resistance.

Authors:  Sally R Partridge; Stephen M Kwong; Neville Firth; Slade O Jensen
Journal:  Clin Microbiol Rev       Date:  2018-08-01       Impact factor: 26.132

3.  Genetic contexts of blaNDM-1.

Authors:  Sally R Partridge; Jonathan R Iredell
Journal:  Antimicrob Agents Chemother       Date:  2012-11       Impact factor: 5.191

4.  Molecular characterization of blaNDM-1 in a sequence type 235 Pseudomonas aeruginosa isolate from France.

Authors:  Frédéric Janvier; Katy Jeannot; Sophie Tessé; Marjorie Robert-Nicoud; Hervé Delacour; Christophe Rapp; Audrey Mérens
Journal:  Antimicrob Agents Chemother       Date:  2013-04-22       Impact factor: 5.191

5.  Genomic Characteristics of NDM-Producing Enterobacteriaceae Isolates in Australia and Their blaNDM Genetic Contexts.

Authors:  Alexander M Wailan; David L Paterson; Karina Kennedy; Paul R Ingram; Evan Bursle; Hanna E Sidjabat
Journal:  Antimicrob Agents Chemother       Date:  2015-10-19       Impact factor: 5.191

Review 6.  B1-Metallo-β-Lactamases: Where Do We Stand?

Authors:  Maria F Mojica; Robert A Bonomo; Walter Fast
Journal:  Curr Drug Targets       Date:  2016       Impact factor: 3.465

7.  DNA uptake by the nosocomial pathogen Acinetobacter baumannii occurs during movement along wet surfaces.

Authors:  Gottfried Wilharm; Janett Piesker; Michael Laue; Evelyn Skiebe
Journal:  J Bacteriol       Date:  2013-07-12       Impact factor: 3.490

8.  Distinct Mechanisms of Dissemination of NDM-1 Metallo-β-Lactamase in Acinetobacter Species in Argentina.

Authors:  Mark D Adams; Fernando Pasteran; German M Traglia; Jasmine Martinez; Fanny Huang; Christine Liu; Jennifer S Fernandez; Carolina Lopez; Lisandro J Gonzalez; Ezequiel Albornoz; Alejandra Corso; Alejandro J Vila; Robert A Bonomo; Maria Soledad Ramirez
Journal:  Antimicrob Agents Chemother       Date:  2020-04-21       Impact factor: 5.191

Review 9.  NDM Metallo-β-Lactamases and Their Bacterial Producers in Health Care Settings.

Authors:  Wenjing Wu; Yu Feng; Guangmin Tang; Fu Qiao; Alan McNally; Zhiyong Zong
Journal:  Clin Microbiol Rev       Date:  2019-01-30       Impact factor: 26.132

10.  Mechanisms Involved in Acquisition of blaNDM Genes by IncA/C2 and IncFIIY Plasmids.

Authors:  Alexander M Wailan; Hanna E Sidjabat; Wan Keat Yam; Nabil-Fareed Alikhan; Nicola K Petty; Anna L Sartor; Deborah A Williamson; Brian M Forde; Mark A Schembri; Scott A Beatson; David L Paterson; Timothy R Walsh; Sally R Partridge
Journal:  Antimicrob Agents Chemother       Date:  2016-06-20       Impact factor: 5.191
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.