Literature DB >> 22314125

The nature, assessment, and treatment of obsessive-compulsive disorder.

Joseph F McGuire1, Adam B Lewin, Betty Horng, Tanya K Murphy, Eric A Storch.   

Abstract

Obsessive-compulsive disorder (OCD) is an anxiety disorder that affects between 1% to 2% of individuals and causes considerable impairment and disability. Although > 50% of individuals experience symptom onset in childhood, symptoms can continue to develop throughout adulthood. Accurate and timely assessment of clinical presentation is critical to limit impairment and improve prognosis. Presently, there are 2 empirically supported treatments available for OCD in children and adults, namely cognitive-behavioral therapy and pharmacotherapy with serotonin reuptake inhibitors. This article provides an introduction to the phenomenology, etiology, and clinical course of OCD. Assessment practices used to evaluate symptom severity are described, and evidence-based treatment options are reviewed, with appropriate distinctions drawn between children and adults. Finally, recommendations for assessment and treatment practices for OCD are explicated.

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Year:  2012        PMID: 22314125     DOI: 10.3810/pgm.2012.01.2528

Source DB:  PubMed          Journal:  Postgrad Med        ISSN: 0032-5481            Impact factor:   3.840


  8 in total

1.  Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice.

Authors:  Kristen K Ade; Yehong Wan; Harold C Hamann; Justin K O'Hare; Weirui Guo; Anna Quian; Sunil Kumar; Srishti Bhagat; Ramona M Rodriguiz; William C Wetsel; P Jeffrey Conn; Kafui Dzirasa; Kimberly M Huber; Nicole Calakos
Journal:  Biol Psychiatry       Date:  2016-05-13       Impact factor: 13.382

2.  Advances in the treatment of pediatric obsessive-compulsive d-cycloserine with exposure and response prevention.

Authors:  Joseph F McGuire; Adam B Lewin; Daniel A Geller; Ashley Brown; Kesley Ramsey; Jane Mutch; Andrew Mittelman; Jamie Micco; Cary Jordan; Sabine Wilhelm; Tanya K Murphy; Brent J Small; Eric A Storch
Journal:  Neuropsychiatry (London)       Date:  2012-08

3.  Marble burying and nestlet shredding as tests of repetitive, compulsive-like behaviors in mice.

Authors:  Mariana Angoa-Pérez; Michael J Kane; Denise I Briggs; Dina M Francescutti; Donald M Kuhn
Journal:  J Vis Exp       Date:  2013-12-24       Impact factor: 1.355

4.  FEAR CONDITIONING AND EXTINCTION IN YOUTH WITH OBSESSIVE-COMPULSIVE DISORDER.

Authors:  Joseph F McGuire; Scott P Orr; Monica S Wu; Adam B Lewin; Brent J Small; Vicky Phares; Tanya K Murphy; Sabine Wilhelm; Daniel S Pine; Daniel Geller; Eric A Storch
Journal:  Depress Anxiety       Date:  2016-01-21       Impact factor: 6.505

Review 5.  Enhancing exposure therapy for anxiety disorders, obsessive-compulsive disorder and post-traumatic stress disorder.

Authors:  Joseph F McGuire; Adam B Lewin; Eric A Storch
Journal:  Expert Rev Neurother       Date:  2014-06-27       Impact factor: 4.618

6.  Sexual obsessions and suicidal behaviors in patients with mood disorders, panic disorder and schizophrenia.

Authors:  Liliana Dell'osso; Giulia Casu; Marina Carlini; Ciro Conversano; Paola Gremigni; Claudia Carmassi
Journal:  Ann Gen Psychiatry       Date:  2012-10-30       Impact factor: 3.455

Review 7.  Evidence-Based Assessment of Obsessive-Compulsive Disorder.

Authors:  Amy M Rapp; R Lindsay Bergman; John Piacentini; Joseph F McGuire
Journal:  J Cent Nerv Syst Dis       Date:  2016-08-21

8.  The Risk of Cancer in Patients With Obsessive-Compulsive Disorder: A Nationwide Population-Based Retrospective Cohort Study.

Authors:  Cheng-Che Shen; Li-Yu Hu; Yu-Wen Hu; Wen-Han Chang; Pei-Ling Tang; Pan-Ming Chen; Tzeng-Ji Chen; Tung-Ping Su
Journal:  Medicine (Baltimore)       Date:  2016-03       Impact factor: 1.889

  8 in total

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