| Literature DB >> 22311359 |
M Jaume1, M S Yip, Y W Kam, C Y Cheung, F Kien, A Roberts, P H Li, I Dutry, N Escriou, M Daeron, R Bruzzone, K Subbarao, J S M Peiris, B Nal, R Altmeyer.
Abstract
1. A SARS vaccine was produced based on recombinant native full-length Spike-protein trimers (triSpike) and efficient establishment of a vaccination procedure in rodents. 2. Antibody-mediated enhancement of SARS-CoV infection with anti-SARS-CoV Spike immune-serum was observed in vitro. 3. Antibody-mediated infection of SARS-CoV triggers entry into human haematopoietic cells via an FcγR-dependent and ACE2-, pH-, cysteine-protease-independent pathways. 4. The antibody-mediated enhancement phenomenon is not a mandatory component of the humoral immune response elicited by SARS vaccines, as pure neutralising antibody only could be obtained. 5. Occurrence of immune-mediated enhancement of SARS-CoV infection raises safety concerns regarding the use of SARS-CoV vaccine in humans and enables new ways to investigate SARS pathogenesis (tropism and immune response deregulation).Entities:
Mesh：
Substances：
Year: 2012 PMID： 22311359
Source DB: PubMed Journal: Hong Kong Med J ISSN： 1024-2708 Impact factor: 2.227