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Literature DB >> 22310641

Vitamin D 25-hydroxylase - Four decades of searching, are we there yet?

Abstract

Bioactivation of vitamin D(3) involves 25-hydroxylation and subsequent 1α-hydroxylation to produce 1α,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], the active hormone. Six cytochrome P450 enzymes (CYP27A1, CYP2R1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) catalyzing the initial 25-hydroxylation step are reviewed, and their physiological relevance as vitamin D 25-hydroxylases in vivo is discussed.

Entities: Chemical Gene

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Year: 2012 PMID： 22310641 DOI： 10.1016/j.abb.2012.01.013

Source DB: PubMed Journal: Arch Biochem Biophys ISSN： 0003-9861 Impact factor: 4.013

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Cited

56 in total

1. Properties of purified CYP2R1 in a reconstituted membrane environment and its 25-hydroxylation of 20-hydroxyvitamin D3.

Authors: Chloe Y S Cheng; Tae-Kang Kim; Saowanee Jeayeng; Andrzej T Slominski; Robert C Tuckey
Journal: J Steroid Biochem Mol Biol Date: 2017-07-14 Impact factor: 4.292

Review 2. Clinical review: The role of the parent compound vitamin D with respect to metabolism and function: Why clinical dose intervals can affect clinical outcomes.

Authors: Bruce W Hollis; Carol L Wagner
Journal: J Clin Endocrinol Metab Date: 2013-10-08 Impact factor: 5.958

Review 3. Vitamin D administration during pregnancy as prevention for pregnancy, neonatal and postnatal complications.

Authors: Carol L Wagner; Bruce W Hollis; Kalliopi Kotsa; Hana Fakhoury; Spyridon N Karras
Journal: Rev Endocr Metab Disord Date: 2017-09 Impact factor: 6.514

4. Fasting-Induced Transcription Factors Repress Vitamin D Bioactivation, a Mechanism for Vitamin D Deficiency in Diabetes.

Authors: Sanna-Mari Aatsinki; Mahmoud-Sobhy Elkhwanky; Outi Kummu; Mikko Karpale; Marcin Buler; Pirkko Viitala; Valtteri Rinne; Maija Mutikainen; Pasi Tavi; Andras Franko; Rudolf J Wiesner; Kari T Chambers; Brian N Finck; Jukka Hakkola
Journal: Diabetes Date: 2019-03-04 Impact factor: 9.461

10. Characterizing antibody cross-reactivity for immunoaffinity purification of analytes prior to multiplexed liquid chromatography-tandem mass spectrometry.

Authors: Thomas J Laha; Frederick G Strathmann; Zhican Wang; Ian H de Boer; Kenneth E Thummel; Andrew N Hoofnagle
Journal: Clin Chem Date: 2012-09-11 Impact factor: 8.327

Vitamin D 25-hydroxylase - Four decades of searching, are we there yet?

1. Properties of purified CYP2R1 in a reconstituted membrane environment and its 25-hydroxylation of 20-hydroxyvitamin D3.

Review 2. Clinical review: The role of the parent compound vitamin D with respect to metabolism and function: Why clinical dose intervals can affect clinical outcomes.

Review 3. Vitamin D administration during pregnancy as prevention for pregnancy, neonatal and postnatal complications.

4. Fasting-Induced Transcription Factors Repress Vitamin D Bioactivation, a Mechanism for Vitamin D Deficiency in Diabetes.

Review 5. Cytochrome P450-mediated metabolism of vitamin D.

Review 6. Immunoregulatory effects and therapeutic potential of vitamin D in multiple sclerosis.

7. CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo.

Review 8. Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment.

Review 9. Vitamin D metabolism, mechanism of action, and clinical applications.

10. Characterizing antibody cross-reactivity for immunoaffinity purification of analytes prior to multiplexed liquid chromatography-tandem mass spectrometry.