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Literature DB >> 22310494

Screening for chemicals that affect hair cell death and survival in the zebrafish lateral line.

Henry Ou¹, Julian A Simon, Edwin W Rubel, David W Raible.

Abstract

The zebrafish lateral line is an efficient model system for the evaluation of chemicals that protect and damage hair cells. Located on the surface of the body, lateral line hair cells are accessible for manipulation and visualization. The zebrafish lateral line system allows rapid screens of large chemical libraries, as well as subsequent thorough evaluation of interesting compounds. In this review, we focus on the results of our previous screens and the evolving methodology of our screens for chemicals that protect hair cells, and chemicals that damage hair cells using the zebrafish lateral line.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Neuroprotective Agents

Year: 2012 PMID： 22310494 PMCID： PMC3371178 DOI： 10.1016/j.heares.2012.01.009

Source DB: PubMed Journal: Hear Res ISSN： 0378-5955 Impact factor: 3.208

75 in total

1. Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis.

Authors: Shinichi Someya; Jinze Xu; Kenji Kondo; Dalian Ding; Richard J Salvi; Tatsuya Yamasoba; Peter S Rabinovitch; Richard Weindruch; Christiaan Leeuwenburgh; Masaru Tanokura; Tomas A Prolla
Journal: Proc Natl Acad Sci U S A Date: 2009-11-09 Impact factor: 11.205

2. Response of mechanosensory hair cells of the zebrafish lateral line to aminoglycosides reveals distinct cell death pathways.

Authors: Kelly N Owens; Allison B Coffin; Lisa S Hong; Keri O'Connell Bennett; Edwin W Rubel; David W Raible
Journal: Hear Res Date: 2009-03-11 Impact factor: 3.208

3. Extracellular divalent cations modulate aminoglycoside-induced hair cell death in the zebrafish lateral line.

Authors: Allison B Coffin; Katherine E Reinhart; Kelly N Owens; David W Raible; Edwin W Rubel
Journal: Hear Res Date: 2009-03-12 Impact factor: 3.208

4. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.

Authors: Duan-Wu Zhang; Jing Shao; Juan Lin; Na Zhang; Bao-Ju Lu; Sheng-Cai Lin; Meng-Qiu Dong; Jiahuai Han
Journal: Science Date: 2009-06-04 Impact factor: 47.728

Review 5. Drug screening for hearing loss: using the zebrafish lateral line to screen for drugs that prevent and cause hearing loss.

Authors: Henry C Ou; Felipe Santos; David W Raible; Julian A Simon; Edwin W Rubel
Journal: Drug Discov Today Date: 2010-01-22 Impact factor: 7.851

6. Activation of cell death pathways in the inner ear of the aging CBA/J mouse.

Authors: Su-Hua Sha; Fu-Quan Chen; Jochen Schacht
Journal: Hear Res Date: 2009-05-05 Impact factor: 3.208

7. The caspase pathway in noise-induced apoptosis of the chinchilla cochlea.

Authors: Thomas M Nicotera; Bo Hua Hu; Donald Henderson
Journal: J Assoc Res Otolaryngol Date: 2003-10-13

Review 8. Zebrafish (Danio rerio) neuromast: promising biological endpoint linking developmental and toxicological studies.

Authors: Mirjam Froehlicher; Anja Liedtke; Ksenia J Groh; Stephan C F Neuhauss; Helmut Segner; Rik I L Eggen
Journal: Aquat Toxicol Date: 2009-04-24 Impact factor: 4.964

9. Developmental differences in susceptibility to neomycin-induced hair cell death in the lateral line neuromasts of zebrafish (Danio rerio).

Authors: Setsuko L Murakami; Lisa L Cunningham; Lynne A Werner; Eric Bauer; Rémy Pujol; David W Raible; Edwin W Rubel
Journal: Hear Res Date: 2003-12 Impact factor: 3.208

Screening for chemicals that affect hair cell death and survival in the zebrafish lateral line.

1. Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis.

2. Response of mechanosensory hair cells of the zebrafish lateral line to aminoglycosides reveals distinct cell death pathways.

3. Extracellular divalent cations modulate aminoglycoside-induced hair cell death in the zebrafish lateral line.

4. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.

Review 5. Drug screening for hearing loss: using the zebrafish lateral line to screen for drugs that prevent and cause hearing loss.

6. Activation of cell death pathways in the inner ear of the aging CBA/J mouse.

7. The caspase pathway in noise-induced apoptosis of the chinchilla cochlea.

Review 8. Zebrafish (Danio rerio) neuromast: promising biological endpoint linking developmental and toxicological studies.

9. Developmental differences in susceptibility to neomycin-induced hair cell death in the lateral line neuromasts of zebrafish (Danio rerio).

Review 10. Chemical screening for hair cell loss and protection in the zebrafish lateral line.

Review 1. Parkinson's disease pathogenesis from the viewpoint of small fish models.

Review 2. Behavioral methods for the functional assessment of hair cells in zebrafish.

Review 3. Effect of intratympanic dimethyl sulphoxide (DMSO) in an in vivo model of cisplatin-related ototoxicity.

4. Cerebrospinal fluid injection into adult zebrafish for disease research.

5. Profiling drug-induced cell death pathways in the zebrafish lateral line.

Review 6. There and back again: development and regeneration of the zebrafish lateral line system.

Review 7. Sensory hair cell regeneration in the zebrafish lateral line.

8. Canertinib induces ototoxicity in three preclinical models.

9. An in vivo platform for rapid high-throughput antitubercular drug discovery.

10. Disruption of intracellular calcium regulation is integral to aminoglycoside-induced hair cell death.