AIM: We investigated the angiogenesis and density of newly formed blood vessels in embryonal tumors in relation to Ki-67, bcl-2, p-53 and p-27 expression. METHODS: Forty-five children with embryonal tumors were enrolled in the study. Forty patients had a medulloblastoma (MB) and 5 patients had atypical teratoid/rhabdoid tumor (AT/RT). RESULTS: In MB, the 5-year PFS and OS was 62.5 and 70%, respectively. Patients with Ki-67 index >50%, bcl-2 index >30% and higher density of new vessels were associated with worse survival. In the multivariate analysis, Ki-67 index was identified as a factor with independent prognostic power. In AT/RTs, high density of new vessels (>25 HRF) was observed in 3 patients and Ki-67 index over 25% was found in 4 patients. CONCLUSION: Increased Ki-67, bcl-2 and density of new vessels are of prognostic value for the disease outcome in MB.
AIM: We investigated the angiogenesis and density of newly formed blood vessels in embryonal tumors in relation to Ki-67, bcl-2, p-53 and p-27 expression. METHODS: Forty-five children with embryonal tumors were enrolled in the study. Forty patients had a medulloblastoma (MB) and 5 patients had atypical teratoid/rhabdoid tumor (AT/RT). RESULTS: In MB, the 5-year PFS and OS was 62.5 and 70%, respectively. Patients with Ki-67 index >50%, bcl-2 index >30% and higher density of new vessels were associated with worse survival. In the multivariate analysis, Ki-67 index was identified as a factor with independent prognostic power. In AT/RTs, high density of new vessels (>25 HRF) was observed in 3 patients and Ki-67 index over 25% was found in 4 patients. CONCLUSION: Increased Ki-67, bcl-2 and density of new vessels are of prognostic value for the disease outcome in MB.
Authors: Christopher S Hong; Winson Ho; Martin G Piazza; Abhik Ray-Chaudhury; Zhengping Zhuang; John D Heiss Journal: J Interdiscip Histopathol Date: 2016
Authors: Francesca Gabriela Paslaru; Anca Maria Panaitescu; Elena Nestian; George Iancu; Alina Veduta; Alexandru Catalin Paslaru; Lucian Gheorghe Pop; Radu Mircea Gorgan Journal: Medicina (Kaunas) Date: 2022-01-14 Impact factor: 2.430