Literature DB >> 22308275

Cocktail of eternity: HDAC meets miR.

Clemens M Wendtner1.   

Abstract

In this issue of Blood, Sampath and colleagues provide an important missing link in how microRNAs (miRs) can be silenced in chronic lymphocytic leukemia (CLL):histone deacetylases (HDACs) that are overexpressed in CLL block critical miRs in the malignant B cell resulting in pro-survival signals. Thus,HDAC inhibition is an attractive new therapeutic strategy in CLL.

Entities:  

Year:  2012        PMID： 22308275     DOI： 10.1182/blood-2011-12-394494

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  5 in total

1.  HDAC Inhibition Induces MicroRNA-182, which Targets RAD51 and Impairs HR Repair to Sensitize Cells to Sapacitabine in Acute Myelogenous Leukemia.

Authors:  Tsung-Huei Lai; Brett Ewald; Alma Zecevic; Chaomei Liu; Melanie Sulda; Dimitrios Papaioannou; Ramiro Garzon; James S Blachly; William Plunkett; Deepa Sampath
Journal:  Clin Cancer Res       Date:  2016-02-08       Impact factor: 12.531

2.  Differential methylation of the micro-RNA 7b gene targets postnatal maturation of murine neuronal Mecp2 gene expression.

Authors:  Yongjun Chen; Bo-Chul Shin; Shanthie Thamotharan; Sherin U Devaskar
Journal:  Dev Neurobiol       Date:  2013-12-09       Impact factor: 3.964

3.  Class II HDAC inhibition hampers hepatic stellate cell activation by induction of microRNA-29.

Authors:  Inge Mannaerts; Nathalie Eysackers; Oscar O Onyema; Katrien Van Beneden; Sergio Valente; Antonello Mai; Margarete Odenthal; Leo A van Grunsven
Journal:  PLoS One       Date:  2013-01-31       Impact factor: 3.240

Review 4.  Regulation of microRNAs by epigenetics and their interplay involved in cancer.

Authors:  Xiaolan Liu; Xiaoyan Chen; Xinfang Yu; Yongguang Tao; Ann M Bode; Zigang Dong; Ya Cao
Journal:  J Exp Clin Cancer Res       Date:  2013-11-22

5.  HDAC 1/4-mediated silencing of microRNA-200b promotes chemoresistance in human lung adenocarcinoma cells.

Authors:  Dong-Qin Chen; Ban-Zhou Pan; Jia-Yuan Huang; Kai Zhang; Shi-Yun Cui; Wei De; Rui Wang; Long-Bang Chen
Journal:  Oncotarget       Date:  2014-05-30
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.