PURPOSE: Pediatric spinal glioblastoma multiforme (GBM) is rare. Evidence-directed management relies on studies in which such cases are only a subset of a larger group. We reviewed cases of pediatric spinal GBM to assess outcomes and identify prognostic factors related to treatment. METHODS: Clinical presentations, radiologic findings, surgical variables, radio- and chemotherapeutic management, and outcomes of eight pathologically proven cases of pediatric spinal GBM were reviewed. RESULTS: Median age was 10 years. All patients presented with motor deficits. Four had sensory symptoms. Average McCormick score at presentation was II. There were three cervical, one cervicothoracic, and four thoracic tumors. Five had cysts. Patients underwent gross total resection (GTR) (n = 4), subtotal resection (STR) (n = 3), or biopsy (n = 1). Four patients improved neurologically after surgery. One patient was lost to follow-up. Seven received both chemo- and radiotherapy. Average overall survival was 15 months. Average survival after STR and GTR were 12.6 and 19.2 months, respectively. In the GTR subset, the 18-month-old patient survived 30 months, while the other two (>10 years) survived an average of 13.75 months. This difference based on age was not seen in the STR subset. Patients survived an average of 17.5 and 10.5 months, respectively, with and without tumoral cysts. Patients with cervical tumors survived an average of 12.5 months, 18.7 months with thoracic tumors, and 11.5 months with a cervicothoracic tumor. CONCLUSIONS: Tumor location, presence of a cyst, gross total resection, and younger age are possible predictors of prolonged survival. Radiotherapy and chemotherapy remain widely used.
PURPOSE: Pediatric spinal glioblastoma multiforme (GBM) is rare. Evidence-directed management relies on studies in which such cases are only a subset of a larger group. We reviewed cases of pediatric spinal GBM to assess outcomes and identify prognostic factors related to treatment. METHODS: Clinical presentations, radiologic findings, surgical variables, radio- and chemotherapeutic management, and outcomes of eight pathologically proven cases of pediatric spinal GBM were reviewed. RESULTS: Median age was 10 years. All patients presented with motor deficits. Four had sensory symptoms. Average McCormick score at presentation was II. There were three cervical, one cervicothoracic, and four thoracic tumors. Five had cysts. Patients underwent gross total resection (GTR) (n = 4), subtotal resection (STR) (n = 3), or biopsy (n = 1). Four patients improved neurologically after surgery. One patient was lost to follow-up. Seven received both chemo- and radiotherapy. Average overall survival was 15 months. Average survival after STR and GTR were 12.6 and 19.2 months, respectively. In the GTR subset, the 18-month-old patient survived 30 months, while the other two (>10 years) survived an average of 13.75 months. This difference based on age was not seen in the STR subset. Patients survived an average of 17.5 and 10.5 months, respectively, with and without tumoral cysts. Patients with cervical tumors survived an average of 12.5 months, 18.7 months with thoracic tumors, and 11.5 months with a cervicothoracic tumor. CONCLUSIONS:Tumor location, presence of a cyst, gross total resection, and younger age are possible predictors of prolonged survival. Radiotherapy and chemotherapy remain widely used.
Authors: Rahul D Tendulkar; Atmaram S Pai Panandiker; Shengjie Wu; Larry E Kun; Alberto Broniscer; Robert A Sanford; Thomas E Merchant Journal: Int J Radiat Oncol Biol Phys Date: 2010-03-24 Impact factor: 7.038
Authors: Stephanie M Perkins; Joshua B Rubin; Jeffrey R Leonard; Matthew D Smyth; Issam El Naqa; Jeff M Michalski; Joseph R Simpson; David L Limbrick; Tae S Park; David B Mansur Journal: Int J Radiat Oncol Biol Phys Date: 2011-01-08 Impact factor: 7.038
Authors: Johannes E A Wolff; Pablo Hernaiz Driever; Bernhard Erdlenbruch; Rolf D Kortmann; Stefan Rutkowski; Torsten Pietsch; Crystal Parker; Monica Warmuth Metz; Astrid Gnekow; Christof M Kramm Journal: Cancer Date: 2010-02-01 Impact factor: 6.860
Authors: Roger Stupp; Monika E Hegi; Warren P Mason; Martin J van den Bent; Martin J B Taphoorn; Robert C Janzer; Samuel K Ludwin; Anouk Allgeier; Barbara Fisher; Karl Belanger; Peter Hau; Alba A Brandes; Johanna Gijtenbeek; Christine Marosi; Charles J Vecht; Karima Mokhtari; Pieter Wesseling; Salvador Villa; Elizabeth Eisenhauer; Thierry Gorlia; Michael Weller; Denis Lacombe; J Gregory Cairncross; René-Olivier Mirimanoff Journal: Lancet Oncol Date: 2009-03-09 Impact factor: 41.316
Authors: Zachary D Guss; Shalini Moningi; George I Jallo; Kenneth J Cohen; Moody D Wharam; Stephanie A Terezakis Journal: Int J Radiat Oncol Biol Phys Date: 2013-02-20 Impact factor: 7.038
Authors: Runze Yang; Albert M Isaacs; Magalie Cadieux; Tomas J Hirmer; Travis S CreveCoeur; Andrew P Lapointe; Michael Opoku-Darko; Zahra Premji; Jay Riva-Cambrin; Clare N Gallagher Journal: Childs Nerv Syst Date: 2021-03-06 Impact factor: 1.475
Authors: Bettina L Serrallach; Brandon H Tran; David F Bauer; Carrie A Mohila; Adekunle M Adesina; Susan L McGovern; Holly B Lindsay; Thierry Agm Huisman Journal: Neuroradiol J Date: 2022-01-06
Authors: Philip J O'Halloran; Michael Farrell; John Caird; Michael Capra; David O'Brien Journal: Childs Nerv Syst Date: 2013-01-15 Impact factor: 1.475
Authors: Hadie Adams; Hieab H H Adams; Christina Jackson; Jordina Rincon-Torroella; George I Jallo; Alfredo Quiñones-Hinojosa Journal: Childs Nerv Syst Date: 2016-01-15 Impact factor: 1.475