Literature DB >> 22307819

Up-front neck dissection followed by concurrent chemoradiation in patients with regionally advanced head and neck cancer.

Peter A Paximadis1, Michael E Christensen, Greg Dyson, Dev P Kamdar, Ammar Sukari, Ho-Sheng Lin, George H Yoo, Harold E Kim.   

Abstract

BACKGROUND: The appropriate management of the neck in patients with regionally advanced head and neck cancer remains controversial. The purpose of this study was to retrospectively analyze our institutional experience with up-front neck dissection followed by definitive chemoradiotherapy.
METHODS: Fifty-five patients with radiographic evidence of large or necrotic lymph nodes underwent up-front neck dissection followed by definitive chemoradiation.
RESULTS: The 5-year overall survival (OS) and progression-free survival (PFS) rates were estimated at 71.3% and 64.7%, respectively. There were 2 failures in the dissected neck, for a control rate of 96.7%. There were 7 locoregional failures and 12 distant failures, for locoregional and distant control rates of 87.3% and 78.2%, respectively.
CONCLUSION: Up-front neck dissection followed by chemoradiotherapy resulted in excellent locoregional control, OS, and PFS. Utilization of this strategy should be considered in carefully selected patients with regionally advanced head and neck cancer. © 2012 Wiley Periodicals, Inc. Head Neck, 2012.
Copyright © 2012 Wiley Periodicals, Inc.

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Year:  2012        PMID： 22307819      PMCID： PMC3870203          DOI： 10.1002/hed.22011

Source DB:  PubMed          Journal:  Head Neck        ISSN： 1043-3074            Impact factor:   3.147


  36 in total

1.  Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer.

Authors:  Arlene A Forastiere; Helmuth Goepfert; Moshe Maor; Thomas F Pajak; Randal Weber; William Morrison; Bonnie Glisson; Andy Trotti; John A Ridge; Clifford Chao; Glen Peters; Ding-Jen Lee; Andrea Leaf; John Ensley; Jay Cooper
Journal:  N Engl J Med       Date:  2003-11-27       Impact factor: 91.245

Review 2.  Regional outcome in oropharyngeal and pharyngolaryngeal cancer treated with high dose per fraction radiotherapy. Analysis of neck disease response in 1646 cases.

Authors:  J Bernier; J P Bataini
Journal:  Radiother Oncol       Date:  1986-06       Impact factor: 6.280

3.  Complications from planned, posttreatment neck dissections.

Authors:  B J Davidson; K A Newkirk; K W Harter; C A Picken; K J Cullen; R B Sessions
Journal:  Arch Otolaryngol Head Neck Surg       Date:  1999-04

4.  Neck dissection for advanced lymph node metastasis before definitive radiotherapy for primary carcinoma of the head and neck.

Authors:  L E Smeele; C R Leemans; C B Reid; R Tiwari; G B Snow
Journal:  Laryngoscope       Date:  2000-07       Impact factor: 3.325

5.  Neck dissection after twice-a-day radiotherapy: morbidity and recurrence rates.

Authors:  J T Parsons; W M Mendenhall; N J Cassisi; S P Stringer; R R Million
Journal:  Head Neck       Date:  1989 Sep-Oct       Impact factor: 3.147

6.  Computed tomographic density of metastatic lymph nodes as a treatment-related prognostic factor in advanced head and neck cancer.

Authors:  J N Munck; E Cvitkovic; J D Piekarski; E Benhamou; G Recondo; M Bachouchi; E Tellez-Bernal; B Luboinski; F Eschwege; P Wibault
Journal:  J Natl Cancer Inst       Date:  1991-04-17       Impact factor: 13.506

7.  Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma.

Authors:  Fabrice Denis; Pascal Garaud; Etienne Bardet; Marc Alfonsi; Christian Sire; Thierry Germain; Philippe Bergerot; Beatrix Rhein; Jacques Tortochaux; Gilles Calais
Journal:  J Clin Oncol       Date:  2003-12-02       Impact factor: 44.544

8.  Prediction of outcome in head-and-neck cancer patients using the standardized uptake value of 2-[18F]fluoro-2-deoxy-D-glucose.

Authors:  Abdelkarim S Allal; Daniel O Slosman; Tayeb Kebdani; Mohamed Allaoua; Willy Lehmann; Pavel Dulguerov
Journal:  Int J Radiat Oncol Biol Phys       Date:  2004-08-01       Impact factor: 7.038

9.  Necessity for adjuvant neck dissection in setting of concurrent chemoradiation for advanced head-and-neck cancer.

Authors:  David M Brizel; Robert G Prosnitz; Shannon Hunter; Samuel R Fisher; Robert L Clough; Mary Ann Downey; Richard L Scher
Journal:  Int J Radiat Oncol Biol Phys       Date:  2004-04-01       Impact factor: 7.038

10.  Squamous cell carcinoma of the head and neck treated with radiation therapy: the role of neck dissection for clinically positive neck nodes.

Authors:  W M Mendenhall; R R Million; N J Cassisi
Journal:  Int J Radiat Oncol Biol Phys       Date:  1986-05       Impact factor: 7.038
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  3 in total

1.  Up-front neck dissection followed by chemoradiotherapy for T1-T3 hypopharyngeal cancer with advanced nodal involvement.

Authors:  Mitsuo P Sato; Naoki Otsuki; Mutsukazu Kitano; Kazuki Ishikawa; Kaoru Tanaka; Takayuki Kimura; Katsumi Doi
Journal:  Head Neck       Date:  2021-09-22       Impact factor: 3.821

2.  Definitive intensity modulated radiotherapy in locally advanced hypopharygeal and laryngeal squamous cell carcinoma: mature treatment results and patterns of locoregional failure.

Authors:  Andreas Geretschläger; Beat Bojaxhiu; Alan Dal Pra; Dominic Leiser; Michael Schmücking; Andreas Arnold; Pirus Ghadjar; Daniel M Aebersold
Journal:  Radiat Oncol       Date:  2015-01-17       Impact factor: 3.481

3.  Three therapeutic regimens based on induction chemotherapy in locally advanced squamous cell carcinoma of the head and neck: a single center experience.

Authors:  Lin Jiang; Liang Guo; Kejing Wang; Shengye Wang; Meiyu Fang; Jianlin Lou
Journal:  Transl Cancer Res       Date:  2020-02       Impact factor: 1.241
  3 in total

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