Literature DB >> 22306886

Altered expression of talin 1 in peripheral immune cells points to a significant role of the innate immune system in spontaneous autoimmune uveitis.

Roxane L Degroote1, Stefanie M Hauck, Elisabeth Kremmer, Barbara Amann, Marius Ueffing, Cornelia A Deeg.   

Abstract

The molecular mechanism which enables activated immune cells to cross the blood-retinal barrier in spontaneous autoimmune uveitis is yet to be unraveled. Equine recurrent uveitis is the only spontaneous animal model allowing us to investigate the autoimmune mediated transformation of leukocytes in the course of this sight threatening disease. Hypothesizing that peripheral blood immune cells change their protein expression pattern in spontaneous autoimmune uveitis, we used DIGE to detect proteins with altered abundance comparing peripheral immune cells of healthy and ERU diseased horses. Among others, we found a significant downregulation of talin 1 in peripheral blood granulocytes of ERU specimen, pointing to changes in β integrin activation and indicating a significant role of the innate immune system in spontaneous autoimmune diseases.
Copyright © 2012. Published by Elsevier B.V.

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Year:  2012        PMID： 22306886     DOI： 10.1016/j.jprot.2012.01.023

Source DB:  PubMed          Journal:  J Proteomics        ISSN： 1874-3919            Impact factor:   4.044


  8 in total

1.  Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis.

Authors:  Margarete E Swadzba; Stefanie M Hauck; Hassan Y Naim; Barbara Amann; Cornelia A Deeg
Journal:  PLoS One       Date:  2012-12-07       Impact factor: 3.240

2.  Unraveling the equine lymphocyte proteome: differential septin 7 expression associates with immune cells in equine recurrent uveitis.

Authors:  Roxane L Degroote; Stefanie M Hauck; Barbara Amann; Sieglinde Hirmer; Marius Ueffing; Cornelia A Deeg
Journal:  PLoS One       Date:  2014-03-10       Impact factor: 3.240

3.  Aquaporin 11, a regulator of water efflux at retinal Müller glial cell surface decreases concomitant with immune-mediated gliosis.

Authors:  Cornelia A Deeg; Barbara Amann; Konstantin Lutz; Sieglinde Hirmer; Karina Lutterberg; Elisabeth Kremmer; Stefanie M Hauck
Journal:  J Neuroinflammation       Date:  2016-04-23       Impact factor: 8.322

4.  Interaction of septin 7 and DOCK8 in equine lymphocytes reveals novel insights into signaling pathways associated with autoimmunity.

Authors:  Melanie Schauer; Kristina J H Kleinwort; Roxane L Degroote; Carmen Wiedemann; Elisabeth Kremmer; Stefanie M Hauck; Cornelia A Deeg
Journal:  Sci Rep       Date:  2018-08-17       Impact factor: 4.379

5.  IL8 and PMA Trigger the Regulation of Different Biological Processes in Granulocyte Activation.

Authors:  Roxane L Degroote; Maria Weigand; Stefanie M Hauck; Cornelia A Deeg
Journal:  Front Immunol       Date:  2020-01-14       Impact factor: 7.561

Review 6.  Immunological Insights in Equine Recurrent Uveitis.

Authors:  Roxane L Degroote; Cornelia A Deeg
Journal:  Front Immunol       Date:  2021-01-08       Impact factor: 7.561

7.  Pre-Activated Granulocytes from an Autoimmune Uveitis Model Show Divergent Pathway Activation Profiles upon IL8 Stimulation In Vitro.

Authors:  Anne L C Hoffmann; Stefanie M Hauck; Cornelia A Deeg; Roxane L Degroote
Journal:  Int J Mol Sci       Date:  2022-08-23       Impact factor: 6.208

8.  Profound re-organization of cell surface proteome in equine retinal pigment epithelial cells in response to in vitro culturing.

Authors:  Christoph M Szober; Stefanie M Hauck; Kerstin N Euler; Kristina J H Fröhlich; Claudia Alge-Priglinger; Marius Ueffing; Cornelia A Deeg
Journal:  Int J Mol Sci       Date:  2012-10-31       Impact factor: 5.923
  8 in total

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