BACKGROUND: Risk assessment of Chagas cardiomyopathy patients is essential for clinical decision making. The ratio of the ratio of early transmitral velocity to tissue Doppler mitral annular early diastolic velocity (E/e') is a powerful predictor of adverse outcome in patients with heart failure. However, its prognostic value remains to be established in the setting of Chagas cardiomyopathy. This study investigated the effect of E/e' on mortality according to different degrees of left ventricular (LV) systolic function in patients with Chagas cardiomyopathy. METHODS: The study prospectively enrolled 232 patients (143 men) with Chagas cardiomyopathy (mean age, 48 ± 12 years). End points were death or cardiac transplantation. RESULTS: During a mean follow-up of 3.4 years, 107 patients had an adverse cardiac event, with an overall events rate of 13.2/year. Cox proportional hazards model was used with New York Heart Association functional class, LV ejection fraction, right ventricular function, indexed left atrial volume, E/e' ratio, and the statistical interaction term between E/e' ratio and LV ejection fraction. The effect of E/e' ratio on mortality depended on the degree of LV systolic dysfunction. An increasing E/e' ratio was a strong predictor of outcome in patients with mild to moderate LV dysfunction but was inversely associated with mortality in patients with severe systolic dysfunction. CONCLUSION: This study demonstrated the role of the interaction between LV ejection fraction and E/e' ratio in predicting prognosis in Chagas cardiomyopathy patients. The E/e' ratio had a stronger prognostic value in patients with mild and moderate LV dysfunction and was inversely associated with mortality in patients with advanced systolic heart failure.
BACKGROUND: Risk assessment of Chagas cardiomyopathypatients is essential for clinical decision making. The ratio of the ratio of early transmitral velocity to tissue Doppler mitral annular early diastolic velocity (E/e') is a powerful predictor of adverse outcome in patients with heart failure. However, its prognostic value remains to be established in the setting of Chagas cardiomyopathy. This study investigated the effect of E/e' on mortality according to different degrees of left ventricular (LV) systolic function in patients with Chagas cardiomyopathy. METHODS: The study prospectively enrolled 232 patients (143 men) with Chagas cardiomyopathy (mean age, 48 ± 12 years). End points were death or cardiac transplantation. RESULTS: During a mean follow-up of 3.4 years, 107 patients had an adverse cardiac event, with an overall events rate of 13.2/year. Cox proportional hazards model was used with New York Heart Association functional class, LV ejection fraction, right ventricular function, indexed left atrial volume, E/e' ratio, and the statistical interaction term between E/e' ratio and LV ejection fraction. The effect of E/e' ratio on mortality depended on the degree of LV systolic dysfunction. An increasing E/e' ratio was a strong predictor of outcome in patients with mild to moderate LV dysfunction but was inversely associated with mortality in patients with severe systolic dysfunction. CONCLUSION: This study demonstrated the role of the interaction between LV ejection fraction and E/e' ratio in predicting prognosis in Chagas cardiomyopathypatients. The E/e' ratio had a stronger prognostic value in patients with mild and moderate LV dysfunction and was inversely associated with mortality in patients with advanced systolic heart failure.
Authors: Mina M Benjamin; Christopher Bianco; Marco Caccamo; George Sokos; Nobuyuki Kagiyama; Sirish Shrestha; Grace Verzosa; Partho P Sengupta Journal: Eur Heart J Cardiovasc Imaging Date: 2020-09-01 Impact factor: 6.875
Authors: Silvio Henrique Barberato; Minna Moreira Dias Romano; Adenalva Lima de Souza Beck; Ana Clara Tude Rodrigues; André Luiz Cerqueira de Almeida; Bruna Morhy Borges Leal Assunção; Eliza de Almeida Gripp; Fabio Villaça Guimarães Filho; Henry Abensur; José Maria Del Castillo; Marcelo Haertel Miglioranza; Marcelo Luiz Campos Vieira; Márcio Vinicius Lins de Barros; Maria do Carmo Pereira Nunes; Maria Estefania Bosco Otto; Renato de Aguiar Hortegal; Rodrigo Bellio de Mattos Barretto; Thais Harada Campos; Vicente Nicoliello de Siqueira; Samira Saady Morhy Journal: Arq Bras Cardiol Date: 2019-08-08 Impact factor: 2.000
Authors: Nayara I Medeiros; Rafaelle C G Fares; Eliza P Franco; Giovane R Sousa; Rafael T Mattos; Ana T Chaves; Maria do Carmo P Nunes; Walderez O Dutra; Rodrigo Correa-Oliveira; Manoel O C Rocha; Juliana A S Gomes Journal: PLoS Negl Trop Dis Date: 2017-01-24
Authors: Sandra de Araújo Costa; Salvador Rassi; Elis Marra da Madeira Freitas; Natália da Silva Gutierrez; Fabiana Miranda Boaventura; Larissa Pereira da Costa Sampaio; João Bastista Masson Silva Journal: Arq Bras Cardiol Date: 2017-03 Impact factor: 2.000
Authors: Giovane R Sousa; Juliana A S Gomes; Marcos Paulo S Damasio; Maria Carmo P Nunes; Henrique S Costa; Nayara I Medeiros; Rafaelle C G Fares; Ana Thereza Chaves; Rodrigo Corrêa-Oliveira; Manoel Otávio C Rocha Journal: PLoS One Date: 2017-03-09 Impact factor: 3.240
Authors: Sindhu Chadalawada; Anis Rassi; Omar Samara; Anthony Monzon; Deepika Gudapati; Lilian Vargas Barahona; Peter Hyson; Stefan Sillau; Luisa Mestroni; Matthew Taylor; Maria da Consolação Vieira Moreira; Kristen DeSanto; Nelson I Agudelo Higuita; Carlos Franco-Paredes; Andrés F Henao-Martínez Journal: ESC Heart Fail Date: 2021-10-30
Authors: Luis E Echeverría; Sergio Alejandro Gómez-Ochoa; Lyda Z Rojas; Karen Andrea García-Rueda; Pedro López-Aldana; Taulant Muka; Carlos A Morillo Journal: Front Cardiovasc Med Date: 2021-11-29