OBJECTIVE: To study the isolation and characterization of the constituent responsible for the cytotoxic activity of the ethanolic extract of stem of Capparis decidua (C. decidua). METHODS: The preliminary cytotoxic effect of isolated compound (β-Sitosterol triacontenate) was investigated by MTT assay on A549 solid tumor cells. RESULTS: IC(50) value of the β-Sitosterol triacontenate was found to be 1 μM. The cytotoxic activity increased in a dose dependent manner in case of β-Sitosterol triacontenate. CONCLUSIONS: The data therefore provide direct evidence for the role of β-Sitosterol triacontenate as a potent antimetastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant cells.
OBJECTIVE: To study the isolation and characterization of the constituent responsible for the cytotoxic activity of the ethanolic extract of stem of Capparis decidua (C. decidua). METHODS: The preliminary cytotoxic effect of isolated compound (β-Sitosterol triacontenate) was investigated by MTT assay on A549 solid tumor cells. RESULTS: IC(50) value of the β-Sitosterol triacontenate was found to be 1 μM. The cytotoxic activity increased in a dose dependent manner in case of β-Sitosterol triacontenate. CONCLUSIONS: The data therefore provide direct evidence for the role of β-Sitosterol triacontenate as a potent antimetastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant cells.
Authors: Mohammad Sekendar Ali; Mohammad Ruhul Amin; Chowdhury Mohammad Imtiaz Kamal; Mohammad Aslam Hossain Journal: Asian Pac J Trop Biomed Date: 2013-06
Authors: Ana P Oliveira; Andressa L N Silva; Lucas G F C Viana; Mariana G Silva; Érica M Lavor; Raimundo G Oliveira-Júnior; Edilson B Alencar-Filho; Ricardo S Lima; Rosemairy L Mendes; Larissa A Rolim; Débora S C Anjos; Leslie R M Ferraz; Pedro J Rolim-Neto; Maria F S Silva; Claudia do Ó Pessoa; Jackson R G S Almeida Journal: Heliyon Date: 2019-11-01
Authors: Ana Paula de Oliveira; Jackson Roberto Guedes da Silva Almeida; Ivanildo Viana Borges; Emanuella Chiara Valença Pereira; Thiala Alves Feitosa; Raira Feitosa Dos Santos; Raimundo Gonçalves de Oliveira-Junior; Larissa Araújo Rolim; Lucas Gustavo Ferreira Cordeiro Viana; Luciano Augusto de Araújo Ribeiro; Alan Diego da Conceição Santos; Pedro José Rolim-Neto Journal: PeerJ Date: 2019-01-15 Impact factor: 2.984