Literature DB >> 22304908

Immune cells exploit a neural circuit to enter the CNS.

Kevin J Tracey1.   

Abstract

Multiple sclerosis (MS) is associated with the appearance of autoreactive T cells in the central nervous system. Using a mouse model of MS, Arima et al. now show that this attack begins at a specific spinal cord location. T cell entry into the CNS is regulated by a reflex neural circuit originating from leg muscle contractions.
Copyright © 2012 Elsevier Inc. All rights reserved.

Entities:  

Year:  2012        PMID： 22304908      PMCID： PMC4544704          DOI： 10.1016/j.cell.2012.01.025

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  5 in total

1.  Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier.

Authors:  Yasunobu Arima; Masaya Harada; Daisuke Kamimura; Jin-Haeng Park; Fuminori Kawano; Fiona E Yull; Tadafumi Kawamoto; Yoichiro Iwakura; Ulrich A K Betz; Gabriel Márquez; Timothy S Blackwell; Yoshinobu Ohira; Toshio Hirano; Masaaki Murakami
Journal:  Cell       Date:  2012-02-03       Impact factor: 41.582

2.  Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit.

Authors:  Mauricio Rosas-Ballina; Peder S Olofsson; Mahendar Ochani; Sergio I Valdés-Ferrer; Yaakov A Levine; Colin Reardon; Michael W Tusche; Valentin A Pavlov; Ulf Andersson; Sangeeta Chavan; Tak W Mak; Kevin J Tracey
Journal:  Science       Date:  2011-09-15       Impact factor: 47.728

Review 3.  Restoring the balance of the autonomic nervous system as an innovative approach to the treatment of rheumatoid arthritis.

Authors:  Frieda A Koopman; Susanne P Stoof; Rainer H Straub; Marjolein A Van Maanen; Margriet J Vervoordeldonk; Paul P Tak
Journal:  Mol Med       Date:  2011-05-20       Impact factor: 6.354

Review 4.  Nonresolving inflammation.

Authors:  Carl Nathan; Aihao Ding
Journal:  Cell       Date:  2010-03-19       Impact factor: 41.582

Review 5.  Reflex control of immunity.

Authors:  Kevin J Tracey
Journal:  Nat Rev Immunol       Date:  2009-06       Impact factor: 53.106
  5 in total
  11 in total

Review 1.  Rethinking inflammation: neural circuits in the regulation of immunity.

Authors:  Peder S Olofsson; Mauricio Rosas-Ballina; Yaakov A Levine; Kevin J Tracey
Journal:  Immunol Rev       Date:  2012-07       Impact factor: 12.988

Review 2.  Neural circuitry and immunity.

Authors:  Valentin A Pavlov; Kevin J Tracey
Journal:  Immunol Res       Date:  2015-12       Impact factor: 2.829

3.  The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells.

Authors:  Jing Chen; Jennifer L Martindale; Carole Cramer; Myriam Gorospe; Ulus Atasoy; Paul D Drew; Shiguang Yu
Journal:  J Biol Chem       Date:  2017-07-06       Impact factor: 5.157

4.  EAE Induction by Passive Transfer of MOG-specific CD4+ T Cells.

Authors:  Yuki Tanaka; Yasunobu Arima; Kotaro Higuchi; Takuto Ohki; Mohamed Elfeky; Mitsutoshi Ota; Daisuke Kamimura; Masaaki Murakami
Journal:  Bio Protoc       Date:  2017-07-05

Review 5.  Neuroimmunology of the atherosclerotic plaque: a morphological approach.

Authors:  Rita Businaro
Journal:  J Neuroimmune Pharmacol       Date:  2012-11-14       Impact factor: 4.147

Review 6.  Neural reflexes in inflammation and immunity.

Authors:  Ulf Andersson; Kevin J Tracey
Journal:  J Exp Med       Date:  2012-06-04       Impact factor: 14.307

7.  A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model.

Authors:  Yasunobu Arima; Daisuke Kamimura; Toru Atsumi; Masaya Harada; Tadafumi Kawamoto; Naoki Nishikawa; Andrea Stofkova; Takuto Ohki; Kotaro Higuchi; Yuji Morimoto; Peter Wieghofer; Yuka Okada; Yuki Mori; Saburo Sakoda; Shizuya Saika; Yoshichika Yoshioka; Issei Komuro; Toshihide Yamashita; Toshio Hirano; Marco Prinz; Masaaki Murakami
Journal:  Elife       Date:  2015-08-11       Impact factor: 8.140

8.  Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit.

Authors:  Yasunobu Arima; Takuto Ohki; Naoki Nishikawa; Kotaro Higuchi; Mitsutoshi Ota; Yuki Tanaka; Junko Nio-Kobayashi; Mohamed Elfeky; Ryota Sakai; Yuki Mori; Tadafumi Kawamoto; Andrea Stofkova; Yukihiro Sakashita; Yuji Morimoto; Masaki Kuwatani; Toshihiko Iwanaga; Yoshichika Yoshioka; Naoya Sakamoto; Akihiko Yoshimura; Mitsuyoshi Takiguchi; Saburo Sakoda; Marco Prinz; Daisuke Kamimura; Masaaki Murakami
Journal:  Elife       Date:  2017-08-15       Impact factor: 8.140

Review 9.  The Gateway Reflex, a Novel Neuro-Immune Interaction for the Regulation of Regional Vessels.

Authors:  Yuki Tanaka; Yasunobu Arima; Daisuke Kamimura; Masaaki Murakami
Journal:  Front Immunol       Date:  2017-10-18       Impact factor: 7.561

10.  Diabetic cardiac autonomic neuropathy, inflammation and cardiovascular disease.

Authors:  Aaron I Vinik; Tomris Erbas; Carolina M Casellini
Journal:  J Diabetes Investig       Date:  2013-01-29       Impact factor: 4.232
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