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Literature DB >> 22303990

Design and synthesis of dephosphono DNA analogues containing 1,2,3-triazole linker and their UV-melting studies with DNA/RNA.

Abstract

This article describes the synthesis of 3'/5' linked 1,2,3-triazolyl dithymidine derivatives, their incorporation into oligonucleotides, and evaluation of their thermal stabilities toward complementary DNA/RNA.

Entities: Chemical

Mesh：

Substances：
Amides
Triazoles
RNA
DNA

Year: 2012 PMID： 22303990 DOI： 10.1080/15257770.2011.644100

Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381

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Cited

7 in total

1. Synthesis and antimicrobial evaluation of ester-linked 1,4-disubstituted 1,2,3-triazoles with a furyl/thienyl moiety.

Authors: C P Kaushik; Raj Luxmi; Dharmendra Singh; Ashwani Kumar
Journal: Mol Divers Date: 2016-11-29 Impact factor: 2.943

2. Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA.

Authors: Pawan Kumar; Afaf H El-Sagheer; Lynda Truong; Tom Brown
Journal: Chem Commun (Camb) Date: 2017-08-03 Impact factor: 6.222

3. Synthesis, Affinity for Complementary RNA and DNA, and Enzymatic Stability of Triazole-Linked Locked Nucleic Acids (t-LNAs).

Authors: Pawan Kumar; Lynda Truong; Ysobel Ruth Baker; Afaf Helmy El-Sagheer; Tom Brown
Journal: ACS Omega Date: 2018-06-27

Design and synthesis of dephosphono DNA analogues containing 1,2,3-triazole linker and their UV-melting studies with DNA/RNA.

1. Synthesis and antimicrobial evaluation of ester-linked 1,4-disubstituted 1,2,3-triazoles with a furyl/thienyl moiety.

2. Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA.

3. Synthesis, Affinity for Complementary RNA and DNA, and Enzymatic Stability of Triazole-Linked Locked Nucleic Acids (t-LNAs).

4. A New 1,5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility.

Review 5. Triazole-Modified Nucleic Acids for the Application in Bioorganic and Medicinal Chemistry.

6. Synthesis and Biological Evaluation of Triazolyl 13α-Estrone-Nucleoside Bioconjugates.

7. Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology.