Literature DB >> 2230240

Circulating immune complex-associated parasite antigens in human onchocerciasis.

R Chandrashekar1, A F Ogunrinade, R M Alvarez, O O Kale, G J Weil.   

Abstract

This study identified and characterized parasite antigens in sera from humans infected with Onchocerca volvulus. Immune complexes were precipitated from human sera with polyethylene glycol and analyzed by immunoblot with rabbit antibodies to O. volvulus. A 23-kDa parasite antigen was detected in sera from 17 of 23 Nigerian onchocerciasis patients and 5 of 10 endemic controls. Other parasite antigens with apparent molecular masses of 62, 66, and 70 kDa were less consistently observed. These antigens were not present in Nigerian or US nonendemic control sera, in sera from patients with various other parasitic infections, or in sera from US patients with autoimmune diseases. Biochemical studies indicated that these antigens are nonglycosylated acidic proteins that do not contain phosphorylcholine. These antigens may be useful as targets for improved diagnostic tests for onchocerciasis based on parasite antigen detection.

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Year:  1990        PMID： 2230240     DOI： 10.1093/infdis/162.5.1159

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  7 in total

1.  Molecular cloning and characterization of recombinant parasite antigens for immunodiagnosis of onchocerciasis.

Authors:  R Chandrashekar; K Masood; R M Alvarez; A F Ogunrinade; R Lujan; F O Richards; G J Weil
Journal:  J Clin Invest       Date:  1991-11       Impact factor: 14.808

2.  Comparison between the skin snip test and simple dot blot assay as potential rapid assessment tools for Onchocerciasis in the postcontrol era in Ghana.

Authors:  G E Guzmán; K Awadzi; N Opoku; R B Narayanan; H O Akuffo
Journal:  Clin Diagn Lab Immunol       Date:  2002-09

3.  Differentiation of pathogenic Entamoeba histolytica infections from nonpathogenic infections by detection of galactose-inhibitable adherence protein antigen in sera and feces.

Authors:  M D Abd-Alla; T F Jackson; V Gathiram; A M el-Hawey; J I Ravdin
Journal:  J Clin Microbiol       Date:  1993-11       Impact factor: 5.948

4.  Identification of circulating parasite acetylcholinesterase in human and rodent filariasis.

Authors:  S Rathaur; S Müller; R M Maizels; R D Walter
Journal:  Parasitol Res       Date:  1992       Impact factor: 2.289

5.  Identification and specificity of a 38 kDa Loa loa antigenic fraction in sera from high-microfilaraemic Gabonese patients.

Authors:  A Walker-Deemin; A Ferrer; F Gauthier; M Kombila; D Richard-Lenoble
Journal:  Parasitol Res       Date:  2003-11-25       Impact factor: 2.289

6.  An Integrated Multiomics Approach to Identify Candidate Antigens for Serodiagnosis of Human Onchocerciasis.

Authors:  Samantha N McNulty; Bruce A Rosa; Peter U Fischer; Jeanne M Rumsey; Petra Erdmann-Gilmore; Kurt C Curtis; Sabine Specht; R Reid Townsend; Gary J Weil; Makedonka Mitreva
Journal:  Mol Cell Proteomics       Date:  2015-10-15       Impact factor: 5.911

7.  Lipid profiling of the filarial nematodes Onchocerca volvulus, Onchocerca ochengi and Litomosoides sigmodontis reveals the accumulation of nematode-specific ether phospholipids in the host.

Authors:  Vera Wewer; Benjamin L Makepeace; Vincent N Tanya; Helga Peisker; Kenneth Pfarr; Achim Hoerauf; Peter Dörmann
Journal:  Int J Parasitol       Date:  2017-07-23       Impact factor: 3.981
  7 in total

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