OBJECTIVE: The purpose of this study was to determine if veterans with posttraumatic stress disorder (PTSD) and mild traumatic brain injury (TBI) are treated differently pharmacologically than patients with PTSD alone. METHODS: A retrospective evaluation of PTSD pharmacotherapy of Operation Enduring Freedom/Operation Iraqi Freedom veterans with PTSD (N=707) was conducted between April 1, 2007, and March 31, 2009. A total of 45 veterans had suffered a mild TBI. RESULTS: Compared with the patients with PTSD alone, the patients with PTSD and TBI were more likely to be prescribed an antidepressant (p<.001), a sedative-hypnotic (p<.001), or an antipsychotic (p=.024). The patients with TBI were also significantly more likely to receive psychotropic polypharmacy (p=.001) and to receive higher doses of psychiatric medications (p=.03). CONCLUSIONS: The differences in drug therapy found in this study may indicate that patients with TBI and PTSD respond differently to treatment than patients with PTSD alone.
OBJECTIVE: The purpose of this study was to determine if veterans with posttraumatic stress disorder (PTSD) and mild traumatic brain injury (TBI) are treated differently pharmacologically than patients with PTSD alone. METHODS: A retrospective evaluation of PTSD pharmacotherapy of Operation Enduring Freedom/Operation Iraqi Freedom veterans with PTSD (N=707) was conducted between April 1, 2007, and March 31, 2009. A total of 45 veterans had suffered a mild TBI. RESULTS: Compared with the patients with PTSD alone, the patients with PTSD and TBI were more likely to be prescribed an antidepressant (p<.001), a sedative-hypnotic (p<.001), or an antipsychotic (p=.024). The patients with TBI were also significantly more likely to receive psychotropic polypharmacy (p=.001) and to receive higher doses of psychiatric medications (p=.03). CONCLUSIONS: The differences in drug therapy found in this study may indicate that patients with TBI and PTSD respond differently to treatment than patients with PTSD alone.
Authors: Daniel G Amen; Cyrus A Raji; Kristen Willeumier; Derek Taylor; Robert Tarzwell; Andrew Newberg; Theodore A Henderson Journal: PLoS One Date: 2015-07-01 Impact factor: 3.240
Authors: Theodore A Henderson; Muriel J van Lierop; Mary McLean; John Michael Uszler; John F Thornton; Yin-Hui Siow; Dan G Pavel; Joe Cardaci; Phil Cohen Journal: Front Psychiatry Date: 2020-04-15 Impact factor: 4.157
Authors: Cyrus A Raji; Kristen Willeumier; Derek Taylor; Robert Tarzwell; Andrew Newberg; Theodore A Henderson; Daniel G Amen Journal: Brain Imaging Behav Date: 2015-09 Impact factor: 3.978
Authors: Clara E Dismuke-Greer; Mulugeta Gebregziabher; Tiarney Ritchwood; Mary Jo Pugh; Rebekah J Walker; Uche S Uchendu; Leonard E Egede Journal: Health Equity Date: 2018-10-25