Literature DB >> 22301872

It takes two to transport, or is it one?

Hyun-Ho Lim, Christopher Miller.   

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Year:  2012        PMID： 22301872     DOI： 10.1038/nsmb.2239

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


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  10 in total

Review 1.  Substrate and drug binding sites in LeuT.

Authors:  Ajeeta Nyola; Nathan K Karpowich; Juan Zhen; Jennifer Marden; Maarten E Reith; Da-Neng Wang
Journal:  Curr Opin Struct Biol       Date:  2010-06-16       Impact factor: 6.809

2.  The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site.

Authors:  Lei Shi; Matthias Quick; Yongfang Zhao; Harel Weinstein; Jonathan A Javitch
Journal:  Mol Cell       Date:  2008-06-20       Impact factor: 17.970

3.  Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters.

Authors:  Atsuko Yamashita; Satinder K Singh; Toshimitsu Kawate; Yan Jin; Eric Gouaux
Journal:  Nature       Date:  2005-07-24       Impact factor: 49.962

4.  Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context.

Authors:  Hui Wang; Johannes Elferich; Eric Gouaux
Journal:  Nat Struct Mol Biol       Date:  2012-01-15       Impact factor: 15.369

5.  X-ray structures of LeuT in substrate-free outward-open and apo inward-open states.

Authors:  Harini Krishnamurthy; Eric Gouaux
Journal:  Nature       Date:  2012-01-09       Impact factor: 49.962

6.  Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.

Authors:  Satinder K Singh; Atsuko Yamashita; Eric Gouaux
Journal:  Nature       Date:  2007-08-08       Impact factor: 49.962

7.  LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.

Authors:  Zheng Zhou; Juan Zhen; Nathan K Karpowich; Regina M Goetz; Christopher J Law; Maarten E A Reith; Da-Neng Wang
Journal:  Science       Date:  2007-08-09       Impact factor: 47.728

8.  Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation.

Authors:  Matthias Quick; Anne-Marie Lund Winther; Lei Shi; Poul Nissen; Harel Weinstein; Jonathan A Javitch
Journal:  Proc Natl Acad Sci U S A       Date:  2009-03-23       Impact factor: 11.205

9.  Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site.

Authors:  Chayne L Piscitelli; Harini Krishnamurthy; Eric Gouaux
Journal:  Nature       Date:  2010-12-23       Impact factor: 49.962

10.  Experimental conditions can obscure the second high-affinity site in LeuT.

Authors:  Matthias Quick; Lei Shi; Britta Zehnpfennig; Harel Weinstein; Jonathan A Javitch
Journal:  Nat Struct Mol Biol       Date:  2012-01-15       Impact factor: 15.369
  10 in total
  2 in total

1.  Biophysical Approaches to the Study of LeuT, a Prokaryotic Homolog of Neurotransmitter Sodium Symporters.

Authors:  Satinder K Singh; Aritra Pal
Journal:  Methods Enzymol       Date:  2015-03-24       Impact factor: 1.600

Review 2.  Monoamine transporters: insights from molecular dynamics simulations.

Authors:  Julie Grouleff; Lucy Kate Ladefoged; Heidi Koldsø; Birgit Schiøtt
Journal:  Front Pharmacol       Date:  2015-10-16       Impact factor: 5.810
  2 in total

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