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Literature DB >> 2230115

Development of B cell lineages during a primary anti-hapten immune response.

Abstract

Cell lineage relationships were examined in large numbers of hybridomas derived from a single mouse at 7 days and from a single mouse at 12 days after a primary immunization. The properties of these developing lineages provide unique insight into their biologic selection and differentiation. The unique VDJ junctions, the characteristics of the somatic mutations, and the nonproductive H chain gene rearrangements observed at day 12 all indicate that the hybridomas were derived from a limited number of progenitor B cells. Clonally related hybridomas were also observed at day 7. The activation of these lineages occurred very early, because somatic variants were strongly selected for within a few days after the primary immunization.

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Year: 1990 PMID： 2230115

Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422

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Cited

7 in total

5. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.

Authors: J Jacob; G Kelsoe
Journal: J Exp Med Date: 1992-09-01 Impact factor: 14.307

6. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.

Authors: J Jacob; R Kassir; G Kelsoe
Journal: J Exp Med Date: 1991-05-01 Impact factor: 14.307

7. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance.

Authors: S Han; B Zheng; J Dal Porto; G Kelsoe
Journal: J Exp Med Date: 1995-12-01 Impact factor: 14.307

7 in total

Development of B cell lineages during a primary anti-hapten immune response.

1. New nucleotide sequence data on the EMBL File Server.

2. New nucleotide sequence data on the EMBL File Server.

3. Immunoglobulin class switching appears to be regulated by B-cell antigen receptor-specific T-cell action.

4. Somatic mutation in constant regions of mouse lambda 1 light chains.

5. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.

6. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.

7. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance.