| Literature DB >> 22300658 |
Vladimir V Kravchenko1, Christian Gloeckner, G Neil Stowe, Young J Kang, Peter S Tobias, John C Mathison, Richard J Ulevitch, Gunnar F Kaufmann, Kim D Janda.
Abstract
Simultaneous activation of signaling pathways requires dynamic assembly of higher-order protein complexes at the cytoplasmic domains of membrane-associated receptors in a stimulus-specific manner. Here, using the paradigm of cellular activation through cytokine and innate immune receptors, we demonstrate the proof-of-principle application of small molecule probes for the dissection of receptor-proximal signaling processes, such as activation of the transcription factor NF-κB and the protein kinase p38.Entities:
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Year: 2012 PMID： 22300658 PMCID： PMC3288742 DOI： 10.1016/j.bmcl.2012.01.024
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823