| Literature DB >> 22300657 |
Naoki Omori1, Naoki Kouyama, Akira Yukimasa, Kana Watanabe, Yasunori Yokota, Hideki Tanioka, Hirohide Nambu, Hideo Yukioka, Norihito Sato, Yukari Tanaka, Kazutaka Sekiguchi, Takayuki Okuno.
Abstract
We report a hit to lead study on a novel benzoxazole NPY Y5 antagonist. Starting from HTS hit 1, structure-activity relationships were developed. Compound 12 showed reduction of food intake and a tendency to suppress body weight gain over the 21-day experimental period.Entities:
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Year: 2012 PMID： 22300657 DOI： 10.1016/j.bmcl.2012.01.027
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823