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Literature DB >> 2229933

Lack of expression of antigens for islet cell antibodies in rat fetal pancreas.

Y Yamashiro¹, H Taniguchi, S Baba, T Taniguchi, S Kodama, S Aono, G Isshiki, T Jinnouchi.

Abstract

It is not clear yet when pancreatic islet cells begin to express antigens for islet cell antibodies (ICA). Therefore, we studied whether human ICA-positive sera, crossreacting with adult rat islet cells, react with fetal and neonatal rat islet cells immunohistologically. The ICA did not react with fetal islet cells. On the other hand, neonatal islet cells over 2-3 weeks of age expressed the reactivities almost similar to those of the adult. It was suspected that pancreatic islet cells started to express their antigens to induce ICA gradually after birth.

Entities: Disease Species

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Year: 1990 PMID： 2229933 DOI： 10.1007/BF03348638

Source DB: PubMed Journal: J Endocrinol Invest ISSN： 0391-4097 Impact factor: 4.256

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References

13 in total

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Lack of expression of antigens for islet cell antibodies in rat fetal pancreas.

1. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies.

2. Islet-cell antibodies and beta-cell function in monozygotic triplets and twins initially discordant for Type I diabetes mellitus.

3. Expression of cytoplasmic islet cell antigens by rat pancreas.

4. A comparison of the epidemiology of youth-onset insulin-dependent diabetes mellitus between Japan and the United States (Allegheny County, Pennsylvania).

5. Epidemiological studies of diabetes mellitus in Denmark: 3. Clinical characteristics and incidence of diabetes among males aged 0 to 19 years.

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