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Literature DB >> 22297541

Protective Effects of Adeno-associated Virus Mediated Brain-derived Neurotrophic Factor Expression on Retinal Ganglion Cells in Diabetic Rats.

Yan Gong¹, Zhan-Ping Chang, Ruo-Tong Ren, Shi-Hui Wei, Huan-Fen Zhou, Xiao-Fei Chen, Bao-Ke Hou, Xin Jin, Mao-Nian Zhang.

Abstract

Adeno-associated virus vector plasmid carrying the expression cassette of brain-derived neurotrophic factor (BDNF), pAAV-BDNF, was constructed and packaged into recombinant adeno-associated virus (rAAV-BDNF). The rAAV-BDNF was intravitreally injected into streptzotocin (STZ)-induced diabetic Sprague-Dawley (SD) Rats. Data showed that over-expression of BDNF could increase alive retinal ganglion cell (RGC) number and improve its function in streptzotocin(STZ)-induced diabetic rats, which might be a new method to treat diabetic neuropathy and retinopathy.

Entities: Chemical Disease Gene Species

Year: 2012 PMID： 22297541 DOI： 10.1007/s10571-011-9779-x

Source DB: PubMed Journal: Cell Mol Neurobiol ISSN： 0272-4340 Impact factor: 5.046

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