Literature DB >> 22297136

Cross-reactive antibody to swine influenza A(H3N2) subtype virus in children and adults before and after immunisation with 2010/11 trivalent inactivated influenza vaccine in Canada, August to November 2010.

D M Skowronski1, G De Serres, N Z Janjua, J L Gardy, V Gilca, M Dionne, M E Hamelin, C Rhéaume, G Boivin.   

Abstract

In pre- and post-immunisation sera from children (17-120 months-old) and adults (20-59 years-old) immunised with 2010/11 trivalent inactivated influenza vaccine, we assessed age-related patterns of sero-susceptibility and vaccine-induced cross-reactive antibodies to a representative swine H3N2 (swH3N2) and a related ancestral human H3N2 (A/Sydney/5/1997) influenza virus. Few children but a greater proportion of adults showed pre-immunisation haemagglutination inhibition titres ≥40 to either virus. Titres increased with age among children but decreased in adults. Fewer than 20% showed a four-fold rise in antibody titres to either virus following immunisation. Further investigation is warranted to guide ongoing risk assessment and response to emerging swine H3N2 viruses.

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Year:  2012        PMID： 22297136     DOI： 10.2807/ese.17.04.20066-en

Source DB:  PubMed          Journal:  Euro Surveill        ISSN： 1025-496X


  18 in total

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10.  H3N2v and other influenza epidemic risk based on age-specific estimates of sero-protection and contact network interactions.

Authors:  Danuta M Skowronski; Flavia S Moser; Naveed Z Janjua; Bahman Davoudi; Krista M English; Dale Purych; Martin Petric; Babak Pourbohloul
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