Literature DB >> 22296985

Ignorance is no excuse: moral judgments are influenced by a genetic variation on the oxytocin receptor gene.

Nora T Walter1, Christian Montag, Sebastian Markett, Andrea Felten, Gesine Voigt, Martin Reuter.   

Abstract

Perspective-taking has become a main focus of studies on moral judgments. Recent fMRI studies have demonstrated that individual differences in brain activation predict moral decision making. In particular, pharmacological studies highlighted the crucial role for the neuropeptide oxytocin in social behavior and emotional perception. In the present study N=154 participants were genotyped for a functional polymorphism (rs2268498) in the promoter region of the OXTR gene. We found a significant difference between carriers and non-carriers of the C-allele in exculpating agents for accidental harms (F((1,152))=11.49, p=.001, η(2)=.07) indicating that carriers of the C-allele rated accidentally committed harm as significantly more blameworthy than non-carriers. This is the first study providing evidence for a genetic contribution to moral judgments.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID: 22296985     DOI: 10.1016/j.bandc.2012.01.003

Source DB:  PubMed          Journal:  Brain Cogn        ISSN: 0278-2626            Impact factor:   2.310


  15 in total

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2.  An interaction between oxytocin and a genetic variation of the oxytocin receptor modulates amygdala activity toward direct gaze: evidence from a pharmacological imaging genetics study.

Authors:  Christian Montag; Carina Sauer; Martin Reuter; Peter Kirsch
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2013-09-27       Impact factor: 5.270

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Journal:  Child Psychiatry Hum Dev       Date:  2022-09-10

4.  Opposing effects of oxytocin on moral judgment in males and females.

Authors:  Dirk Scheele; Nadine Striepens; Keith M Kendrick; Christine Schwering; Janka Noelle; Andrea Wille; Thomas E Schläpfer; Wolfgang Maier; René Hurlemann
Journal:  Hum Brain Mapp       Date:  2014-08-05       Impact factor: 5.038

5.  The behavioral and neural basis of empathic blame.

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Journal:  Sci Rep       Date:  2017-07-12       Impact factor: 4.379

6.  How Oxytocin Receptor (OXTR) Single Nucleotide Polymorphisms Act on Prosociality: The Mediation Role of Moral Evaluation.

Authors:  Siyuan Shang; Nan Wu; Yanjie Su
Journal:  Front Psychol       Date:  2017-03-21

7.  Sex, receptors, and attachment: a review of individual factors influencing response to oxytocin.

Authors:  Kai S Macdonald
Journal:  Front Neurosci       Date:  2013-01-10       Impact factor: 4.677

8.  Genetic modulation of oxytocin sensitivity: a pharmacogenetic approach.

Authors:  F S Chen; R Kumsta; F Dvorak; G Domes; O S Yim; R P Ebstein; M Heinrichs
Journal:  Transl Psychiatry       Date:  2015-10-27       Impact factor: 6.222

9.  Variation in the oxytocin receptor gene (OXTR) is associated with differences in moral judgment.

Authors:  Regan M Bernhard; Jonathan Chaponis; Richie Siburian; Patience Gallagher; Katherine Ransohoff; Daniel Wikler; Roy H Perlis; Joshua D Greene
Journal:  Soc Cogn Affect Neurosci       Date:  2016-08-06       Impact factor: 3.436

10.  Genetically-Driven Enhancement of Dopaminergic Transmission Affects Moral Acceptability in Females but Not in Males: A Pilot Study.

Authors:  Silvia Pellegrini; Sara Palumbo; Caterina Iofrida; Erika Melissari; Giuseppina Rota; Veronica Mariotti; Teresa Anastasio; Andrea Manfrinati; Rino Rumiati; Lorella Lotto; Michela Sarlo; Pietro Pietrini
Journal:  Front Behav Neurosci       Date:  2017-08-29       Impact factor: 3.558

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