BACKGROUND & AIMS: Systematic reviews of case-control studies evaluating the relationship between dietary salt intake and gastric cancer showed a positive association, however a quantitative analysis of longitudinal cohort studies is lacking. Therefore, we carried out a meta-analysis to assess the association between habitual salt intake and risk of gastric cancer in prospective studies. METHODS: We performed a systematic search of published articles (1966-2010). Criteria for inclusion were: original articles, prospective adult population studies, assessment of salt intake as baseline exposure and of gastric cancer as outcome, follow-up of at least 4 years, indication of number of participants exposed and events across different salt intake categories. RESULTS: Seven studies (10 cohorts) met the inclusion criteria (268 718 participants, 1474 events, follow-up 6-15 years). In the pooled analysis, "high" and "moderately high" vs "low" salt intake were both associated with increased risk of gastric cancer (RR = 1.68 [95% C.I. 1.17-2.41], p = 0.005 and respectively 1.41 [1.03-1.93], p = 0.032), with no evidence of publication bias. The association was stronger in the Japanese population and higher consumption of selected salt-rich foods was also associated with greater risk. Meta-regression analyses did not detect specific sources of heterogeneity. CONCLUSIONS: Dietary salt intake was directly associated with risk of gastric cancer in prospective population studies, with progressively increasing risk across consumption levels.
BACKGROUND & AIMS: Systematic reviews of case-control studies evaluating the relationship between dietary salt intake and gastric cancer showed a positive association, however a quantitative analysis of longitudinal cohort studies is lacking. Therefore, we carried out a meta-analysis to assess the association between habitual salt intake and risk of gastric cancer in prospective studies. METHODS: We performed a systematic search of published articles (1966-2010). Criteria for inclusion were: original articles, prospective adult population studies, assessment of salt intake as baseline exposure and of gastric cancer as outcome, follow-up of at least 4 years, indication of number of participants exposed and events across different salt intake categories. RESULTS: Seven studies (10 cohorts) met the inclusion criteria (268 718 participants, 1474 events, follow-up 6-15 years). In the pooled analysis, "high" and "moderately high" vs "low" salt intake were both associated with increased risk of gastric cancer (RR = 1.68 [95% C.I. 1.17-2.41], p = 0.005 and respectively 1.41 [1.03-1.93], p = 0.032), with no evidence of publication bias. The association was stronger in the Japanese population and higher consumption of selected salt-rich foods was also associated with greater risk. Meta-regression analyses did not detect specific sources of heterogeneity. CONCLUSIONS: Dietary salt intake was directly associated with risk of gastric cancer in prospective population studies, with progressively increasing risk across consumption levels.
Authors: Haejin In; Marisa Langdon-Embry; Lauren Gordon; Clyde B Schechter; Judith Wylie-Rosett; Philip E Castle; M Margaret Kemeny; Bruce D Rapkin Journal: J Surg Res Date: 2018-04-03 Impact factor: 2.192
Authors: Norm R C Campbell; Daniel T Lackland; Liu Lisheng; Xin-Hua Zhang; Peter M Nilsson; Mark L Niebylski Journal: Cardiovasc Diagn Ther Date: 2015-06
Authors: Valeria M Saglimbene; Germaine Wong; Jonathan C Craig; Marinella Ruospo; Suetonia C Palmer; Katrina Campbell; Vanessa Garcia-Larsen; Patrizia Natale; Armando Teixeira-Pinto; Juan-Jesus Carrero; Peter Stenvinkel; Letizia Gargano; Angelo M Murgo; David W Johnson; Marcello Tonelli; Rubén Gelfman; Eduardo Celia; Tevfik Ecder; Amparo G Bernat; Domingo Del Castillo; Delia Timofte; Marietta Török; Anna Bednarek-Skublewska; Jan Duława; Paul Stroumza; Susanne Hoischen; Martin Hansis; Elisabeth Fabricius; Paolo Felaco; Charlotta Wollheim; Jörgen Hegbrant; Giovanni F M Strippoli Journal: J Am Soc Nephrol Date: 2018-04-25 Impact factor: 10.121
Authors: Patricia Bonequi; Fernando Meneses-González; Pelayo Correa; Charles S Rabkin; M Constanza Camargo Journal: Cancer Causes Control Date: 2012-12-07 Impact factor: 2.506