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Literature DB >> 22296405

Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers.

Amit Gangar¹, Adrian Fegan, Sidath C Kumarapperuma, Carston R Wagner.

Abstract

Dihydrofolate reductase single-chain variable fragment (scFv) fusion proteins can be used for the targeted cellular delivery of oligonucleotides, conjugated small molecules, and proteins via labeling of oligonucleotides by bis-methotrexate.

Entities: CellLine Chemical Disease Gene Mutation

Mesh：

Substances：

Year: 2012 PMID： 22296405 PMCID： PMC3312035 DOI： 10.1021/ja210894g

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

12 in total

1. Chemically programmed monoclonal antibodies for cancer therapy: adaptor immunotherapy based on a covalent antibody catalyst.

Authors: Christoph Rader; Subhash C Sinha; Mikhail Popkov; Richard A Lerner; Carlos F Barbas
Journal: Proc Natl Acad Sci U S A Date: 2003-04-17 Impact factor: 11.205

2. Potent inhibition of HIV-1 entry with a chemically programmed antibody aided by an efficient organocatalytic synthesis.

Authors: Julia Gavrilyuk; Hisatoshi Uehara; Nobumasa Otsubo; Ann Hessell; Dennis R Burton; Carlos F Barbas
Journal: Chembiochem Date: 2010-10-18 Impact factor: 3.164

3. Chemically self-assembled antibody nanorings (CSANs): design and characterization of an anti-CD3 IgM biomimetic.

Authors: Qing Li; Christopher R So; Adrian Fegan; Vivian Cody; Mehmet Sarikaya; Daniel A Vallera; Carston R Wagner
Journal: J Am Chem Soc Date: 2010-11-15 Impact factor: 15.419

4. Expanding the concept of chemically programmable antibodies to RNA aptamers: chemically programmed biotherapeutics.

Authors: Ulrich Wuellner; Julia I Gavrilyuk; Carlos F Barbas
Journal: Angew Chem Int Ed Engl Date: 2010-08-09 Impact factor: 15.336

Review 5. Antibody-drug conjugates: targeted drug delivery for cancer.

Authors: Stephen C Alley; Nicole M Okeley; Peter D Senter
Journal: Curr Opin Chem Biol Date: 2010-07-17 Impact factor: 8.822

6. Self-assembly of antibodies by chemical induction.

Authors: Qing Li; David Hapka; Hua Chen; Daniel A Vallera; Carston R Wagner
Journal: Angew Chem Int Ed Engl Date: 2008 Impact factor: 15.336

Review 7. Therapeutic potential of anticancer immunotoxins.

Authors: Swati Choudhary; Mrudula Mathew; Rama S Verma
Journal: Drug Discov Today Date: 2011-04-12 Impact factor: 7.851

Review 8. Humanized immunotoxins: a new generation of immunotoxins for targeted cancer therapy.

Authors: Mrudula Mathew; Rama S Verma
Journal: Cancer Sci Date: 2009-05-19 Impact factor: 6.716

9. A mechanism of resistance to methotrexate. NADPH but not NADH stimulation of methotrexate binding to dihydrofolate reductase.

Authors: B A Kamen; W Whyte-Bauer; J R Bertino
Journal: Biochem Pharmacol Date: 1983-06-15 Impact factor: 5.858

Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers.

1. Chemically programmed monoclonal antibodies for cancer therapy: adaptor immunotherapy based on a covalent antibody catalyst.

2. Potent inhibition of HIV-1 entry with a chemically programmed antibody aided by an efficient organocatalytic synthesis.

3. Chemically self-assembled antibody nanorings (CSANs): design and characterization of an anti-CD3 IgM biomimetic.

4. Expanding the concept of chemically programmable antibodies to RNA aptamers: chemically programmed biotherapeutics.

Review 5. Antibody-drug conjugates: targeted drug delivery for cancer.

6. Self-assembly of antibodies by chemical induction.

Review 7. Therapeutic potential of anticancer immunotoxins.

Review 8. Humanized immunotoxins: a new generation of immunotoxins for targeted cancer therapy.

9. A mechanism of resistance to methotrexate. NADPH but not NADH stimulation of methotrexate binding to dihydrofolate reductase.

Review 10. Targeted cancer therapy: conferring specificity to cytotoxic drugs.

1. Eradication of Established Tumors by Chemically Self-Assembled Nanoring Labeled T Cells.

2. In Vivo Evaluation of Site-Specifically PEGylated Chemically Self-Assembled Protein Nanostructures.

3. Targeted delivery of antisense oligonucleotides by chemically self-assembled nanostructures.

4. Simultaneous dual protein labeling using a triorthogonal reagent.