BACKGROUND: After inadequate response to an antitumour necrosis factor (aTNF) agent for treatment of rheumatoid arthritis (RA), rheumatologists can choose an alternative aTNF or a biological agent with another mode of action (non-aTNF biological (non-aTNF-Bio)). OBJECTIVE: To compare drug retention rates of non-aTNF-Bio with alternative aTNF. METHODS: All patients within the Swiss RA cohort (SCQM-RA) treated with an alternative biotherapy after a prior inadequate response to aTNF were analysed. The drug retention of alternative aTNF was compared with non-aTNF-Bio using Cox proportional hazards models, adjusted for potential confounders. RESULTS: 1485 treatment courses after aTNF failure were available for analysis, 853 with alternative aTNF and 632 with non-aTNF-Bio. The median drug retention was 32 months (IQR 14-54) on non-aTNF-Bio versus 21 months (IQR 8-53) on alternative aTNF, or a 50% reduction drug discontinuation risk in favour of non-aTNF-Bio (adjusted hazard ratio (HR) for non-aTNF-Bio: 0.50 (95% CI 0.41 to 0.62)). This effect appears to be modified by the type of prior aTNF failure, with a larger difference in favour of non-aTNF-Bio in patients having experienced a primary failure with a previous aTNF (HR: 0.33 (95% CI 0.24 to 0.47), p<0.001). CONCLUSION: After inadequate response to aTNF, and particularly after primary failure, patients on a non-aTNF-Bio agent have significantly higher drug retention rates.
BACKGROUND: After inadequate response to an antitumour necrosis factor (aTNF) agent for treatment of rheumatoid arthritis (RA), rheumatologists can choose an alternative aTNF or a biological agent with another mode of action (non-aTNF biological (non-aTNF-Bio)). OBJECTIVE: To compare drug retention rates of non-aTNF-Bio with alternative aTNF. METHODS: All patients within the Swiss RA cohort (SCQM-RA) treated with an alternative biotherapy after a prior inadequate response to aTNF were analysed. The drug retention of alternative aTNF was compared with non-aTNF-Bio using Cox proportional hazards models, adjusted for potential confounders. RESULTS: 1485 treatment courses after aTNF failure were available for analysis, 853 with alternative aTNF and 632 with non-aTNF-Bio. The median drug retention was 32 months (IQR 14-54) on non-aTNF-Bio versus 21 months (IQR 8-53) on alternative aTNF, or a 50% reduction drug discontinuation risk in favour of non-aTNF-Bio (adjusted hazard ratio (HR) for non-aTNF-Bio: 0.50 (95% CI 0.41 to 0.62)). This effect appears to be modified by the type of prior aTNF failure, with a larger difference in favour of non-aTNF-Bio in patients having experienced a primary failure with a previous aTNF (HR: 0.33 (95% CI 0.24 to 0.47), p<0.001). CONCLUSION: After inadequate response to aTNF, and particularly after primary failure, patients on a non-aTNF-Bio agent have significantly higher drug retention rates.
Authors: C Tzanetakos; A Tzioufas; A Goules; G Kourlaba; T Theodoratou; P Christou; N Maniadakis Journal: Rheumatol Int Date: 2017-05-18 Impact factor: 2.631
Authors: Nuria C Navarro Coy; Sarah Brown; Ailsa Bosworth; Claire T Davies; Paul Emery; Colin C Everett; Catherine Fernandez; Janine C Gray; Suzanne Hartley; Claire Hulme; Anne-Maree Keenan; Christopher McCabe; Anthony Redmond; Catherine Reynolds; David Scott; Linda D Sharples; Sue Pavitt; Maya H Buch Journal: BMC Musculoskelet Disord Date: 2014-12-23 Impact factor: 2.362
Authors: Hubert G Nüßlein; Rieke Alten; Mauro Galeazzi; Hanns-Martin Lorenz; Dimitrios Boumpas; Michael T Nurmohamed; William G Bensen; Gerd R Burmester; Hans-Hartmut Peter; Franz Rainer; Karel Pavelka; Melanie Chartier; Coralie Poncet; Christiane Rauch; Manuela Le Bars Journal: BMC Musculoskelet Disord Date: 2014-01-11 Impact factor: 2.362
Authors: Ignacio Ortea; Bernd Roschitzki; Rosario López-Rodríguez; Eva G Tomero; Juan G Ovalles; Javier López-Longo; Inmaculada de la Torre; Isidoro González-Alvaro; Juan J Gómez-Reino; Antonio González Journal: PLoS One Date: 2016-04-06 Impact factor: 3.240