Literature DB >> 22293557

Deal watch: Abbott boosts investment in NRF2 activators for reducing oxidative stress.

Sarah Crunkhorn.   

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Year:  2012        PMID： 22293557     DOI： 10.1038/nrd3655

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


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  1 in total

1.  Bardoxolone methyl and kidney function in CKD with type 2 diabetes.

Authors:  Pablo E Pergola; Philip Raskin; Robert D Toto; Colin J Meyer; J Warren Huff; Eric B Grossman; Melissa Krauth; Stacey Ruiz; Paul Audhya; Heidi Christ-Schmidt; Janet Wittes; David G Warnock
Journal:  N Engl J Med       Date:  2011-06-24       Impact factor: 91.245
  1 in total
  25 in total

1.  Developmental and activity-dependent expression of LanCL1 confers antioxidant activity required for neuronal survival.

Authors:  Chao Huang; Mina Chen; Dejiang Pang; Dandan Bi; Yi Zou; Xiaoqiang Xia; Weiwei Yang; Liping Luo; Rongkang Deng; Honglin Tan; Liang Zhou; Shouyang Yu; Liheng Guo; XiaoXia Du; Yiyuan Cui; Jiahua Hu; Qing Mao; Paul F Worley; Bo Xiao
Journal:  Dev Cell       Date:  2014-08-25       Impact factor: 12.270

Review 2.  Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway.

Authors:  B G Richardson; A D Jain; T E Speltz; T W Moore
Journal:  Bioorg Med Chem Lett       Date:  2015-04-16       Impact factor: 2.823

Review 3.  Multi-target drugs to address multiple checkpoints in complex inflammatory pathologies: evolutionary cues for novel "first-in-class" anti-inflammatory drug candidates: a reviewer's perspective.

Authors:  Geetha Mathew; M K Unnikrishnan
Journal:  Inflamm Res       Date:  2015-07-18       Impact factor: 4.575

4.  β-TrCP1 Is a Vacillatory Regulator of Wnt Signaling.

Authors:  Marcus John Long; Hong-Yu Lin; Saba Parvez; Yi Zhao; Jesse Richard Poganik; Paul Huang; Yimon Aye
Journal:  Cell Chem Biol       Date:  2017-07-20       Impact factor: 8.116

5.  Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors.

Authors:  Benjamin G Richardson; Atul D Jain; Haranatha R Potteti; Phillip R Lazzara; Brian P David; Chandra R Tamatam; Ewelina Choma; Kornelia Skowron; Katherine Dye; Zamia Siddiqui; Yue-Ting Wang; Aleksej Krunic; Sekhar P Reddy; Terry W Moore
Journal:  J Med Chem       Date:  2018-08-31       Impact factor: 7.446

6.  T-REX on-demand redox targeting in live cells.

Authors:  Saba Parvez; Marcus J C Long; Hong-Yu Lin; Yi Zhao; Joseph A Haegele; Vanha N Pham; Dustin K Lee; Yimon Aye
Journal:  Nat Protoc       Date:  2016-10-27       Impact factor: 13.491

Review 7.  Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2.

Authors:  Qiang Ma; Xiaoqing He
Journal:  Pharmacol Rev       Date:  2012-09-10       Impact factor: 25.468

8.  Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators.

Authors:  Atul D Jain; Haranatha Potteti; Benjamin G Richardson; Laura Kingsley; Julia P Luciano; Aya F Ryuzoji; Hyun Lee; Aleksej Krunic; Andrew D Mesecar; Sekhar P Reddy; Terry W Moore
Journal:  Eur J Med Chem       Date:  2015-09-04       Impact factor: 6.514

9.  Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans.

Authors:  Elena V Knatko; Sally H Ibbotson; Ying Zhang; Maureen Higgins; Jed W Fahey; Paul Talalay; Robert S Dawe; James Ferguson; Jeffrey T-J Huang; Rosemary Clarke; Suqing Zheng; Akira Saito; Sukirti Kalra; Andrea L Benedict; Tadashi Honda; Charlotte M Proby; Albena T Dinkova-Kostova
Journal:  Cancer Prev Res (Phila)       Date:  2015-03-24

10.  Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex.

Authors:  Liam Baird; David Llères; Sam Swift; Albena T Dinkova-Kostova
Journal:  Proc Natl Acad Sci U S A       Date:  2013-08-28       Impact factor: 11.205
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