| Literature DB >> 22293500 |
Hitomi Masuda1, Kuniaki Nakamura, Nozomu Takata, Bunsho Itoh, Takashi Hirose, Hiroki Moribe, Eisuke Mekada, Masato Okada.
Abstract
The transmembrane protein MIG-13 is a key regulator required for anterior migration of neural cells in Caenorhabditis elegans, but the signaling mechanisms involved remain unknown. Here, we isolated a suppressor mutation in the unc-71/adm-1 gene, which rescued the AVM neuron migration defect in mig-13 mutants. Genetic analyses revealed that UNC-71 at least partly acts downstream of MIG-13 and has an inhibitory effect on the anterior cell migration. The unc-71 mutation also rescued the anterior migration defect of AVM neuron in src-1 mutants. These findings suggest that MIG-13 controls anteroposterior cell migration by interacting with UNC-71 and SRC-1 in C. elegans. Copyright ÂEntities:
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Year: 2012 PMID： 22293500 DOI： 10.1016/j.febslet.2012.01.031
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124