Literature DB >> 22293185

From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma.

Vladimir Ratushny1, Michael D Gober, Ryan Hick, Todd W Ridky, John T Seykora.   

Abstract

Cutaneous squamous cell carcinoma (cSCC) is the second most common human cancer with over 250,000 new cases annually in the US and is second in incidence only to basal cell carcinoma. cSCC typically manifests as a spectrum of progressively advanced malignancies, ranging from a precursor actinic keratosis (AK) to squamous cell carcinoma (SCC) in situ (SCCIS), invasive cSCC, and finally metastatic SCC. In this Review we discuss clinical and molecular parameters used to define this range of cutaneous neoplasia and integrate these with the multiple experimental approaches used to study this disease. Insights gained from modeling cSCCs have suggested innovative therapeutic targets for treating these lesions.

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Year:  2012        PMID： 22293185      PMCID： PMC3266779          DOI： 10.1172/JCI57415

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  107 in total

1.  Epidermal growth factor receptor gene numerical aberrations are frequent events in actinic keratoses and invasive cutaneous squamous cell carcinomas.

Authors:  Agustí Toll; Rocío Salgado; Mireia Yébenes; Gemma Martín-Ezquerra; Montserrat Gilaberte; Teresa Baró; Francesc Solé; Francisco Alameda; Blanca Espinet; Ramon Maria Pujol
Journal:  Exp Dermatol       Date:  2010-02       Impact factor: 3.960

2.  Expression of P27, Ki67 and P53 in squamous cell carcinoma, actinic keratosis and Bowen disease.

Authors:  S Talghini; M Halimi; H Baybordi
Journal:  Pak J Biol Sci       Date:  2009-06-15

3.  Srcasm inhibits Fyn-induced cutaneous carcinogenesis with modulation of Notch1 and p53.

Authors:  Liang Zhao; Weijie Li; Christine Marshall; Thomas Griffin; Matthew Hanson; Ryan Hick; Tzvete Dentchev; Erik Williams; Adrienne Werth; Christopher Miller; Hasan Bashir; Warren Pear; John T Seykora
Journal:  Cancer Res       Date:  2009-12-15       Impact factor: 12.701

4.  Actinic keratoses: Natural history and risk of malignant transformation in the Veterans Affairs Topical Tretinoin Chemoprevention Trial.

Authors:  Vincent D Criscione; Martin A Weinstock; Mark F Naylor; Claudia Luque; Melody J Eide; Stephen F Bingham
Journal:  Cancer       Date:  2009-06-01       Impact factor: 6.860

5.  Loss of protein kinase C delta gene expression in human squamous cell carcinomas: a laser capture microdissection study.

Authors:  Vipin Yadav; Nicole C Yanez; Sarah E Fenton; Mitchell F Denning
Journal:  Am J Pathol       Date:  2010-01-21       Impact factor: 4.307

6.  Quality of life in the actinic neoplasia syndrome: The VA Topical Tretinoin Chemoprevention (VATTC) Trial.

Authors:  Martin A Weinstock; Kachiu C Lee; Mary-Margaret Chren; Kimberly Marcolivio
Journal:  J Am Acad Dermatol       Date:  2009-04-26       Impact factor: 11.527

7.  Chronic phototoxicity and aggressive squamous cell carcinoma of the skin in children and adults during treatment with voriconazole.

Authors:  Edward W Cowen; Josephine C Nguyen; Daniel D Miller; Diana McShane; Sarah T Arron; Neil S Prose; Maria L Turner; Lindy P Fox
Journal:  J Am Acad Dermatol       Date:  2009-11-06       Impact factor: 11.527

8.  Modeling inducible human tissue neoplasia identifies an extracellular matrix interaction network involved in cancer progression.

Authors:  Jason A Reuter; Susana Ortiz-Urda; Markus Kretz; John Garcia; Florence A Scholl; Anna M G Pasmooij; David Cassarino; Howard Y Chang; Paul A Khavari
Journal:  Cancer Cell       Date:  2009-06-02       Impact factor: 31.743

9.  Increased invasive behaviour in cutaneous squamous cell carcinoma with loss of basement-membrane type VII collagen.

Authors:  Vera L Martins; Jashmin J Vyas; Mei Chen; Karin Purdie; Charles A Mein; Andrew P South; Alan Storey; John A McGrath; Edel A O'Toole
Journal:  J Cell Sci       Date:  2009-05-12       Impact factor: 5.285

10.  MYC gene numerical aberrations in actinic keratosis and cutaneous squamous cell carcinoma.

Authors:  A Toll; R Salgado; M Yébenes; G Martín-Ezquerra; M Gilaberte; T Baró; F Solé; F Alameda; B Espinet; R M Pujol
Journal:  Br J Dermatol       Date:  2009-06-11       Impact factor: 9.302
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  168 in total

Review 1.  Synergy of understanding dermatologic disease and epidermal biology.

Authors:  John R Stanley
Journal:  J Clin Invest       Date:  2012-02-01       Impact factor: 14.808

2.  Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17.

Authors:  Juan Guinea-Viniegra; Rainer Zenz; Harald Scheuch; María Jiménez; Latifa Bakiri; Peter Petzelbauer; Erwin F Wagner
Journal:  J Clin Invest       Date:  2012-07-09       Impact factor: 14.808

3.  Epithelial stem cell mutations that promote squamous cell carcinoma metastasis.

Authors:  Ruth A White; Jill M Neiman; Anand Reddi; Gangwen Han; Stanca Birlea; Doyel Mitra; Laikuan Dionne; Pam Fernandez; Kazutoshi Murao; Li Bian; Stephen B Keysar; Nathaniel B Goldstein; Ningjing Song; Sophia Bornstein; Zheyi Han; Xian Lu; Joshua Wisell; Fulun Li; John Song; Shi-Long Lu; Antonio Jimeno; Dennis R Roop; Xiao-Jing Wang
Journal:  J Clin Invest       Date:  2013-09-03       Impact factor: 14.808

Review 4.  [Actinic keratosis, Bowen's disease, keratoacanthoma and squamous cell carcinoma of the skin].

Authors:  M Majores; E Bierhoff
Journal:  Pathologe       Date:  2015-02       Impact factor: 1.011

5.  An unusual case of multiple melanoma and non-melanoma skin cancers of the leg.

Authors:  Maria Giuseppina Onesti; Paolo Fioramonti; Vittoria Amorosi; Pasquale Fino
Journal:  Int Wound J       Date:  2013-06-24       Impact factor: 3.315

6.  An Expression Signature as an Aid to the Histologic Classification of Non-Small Cell Lung Cancer.

Authors:  Luc Girard; Jaime Rodriguez-Canales; Carmen Behrens; Debrah M Thompson; Ihab W Botros; Hao Tang; Yang Xie; Natasha Rekhtman; William D Travis; Ignacio I Wistuba; John D Minna; Adi F Gazdar
Journal:  Clin Cancer Res       Date:  2016-06-28       Impact factor: 12.531

7.  Mammary Precancerous Stem and Non-Stem Cells Evolve into Cancers of Distinct Subtypes.

Authors:  Wen Bu; Zhenyu Liu; Weiyu Jiang; Chandandeep Nagi; Shixia Huang; Dean P Edwards; Eunji Jo; Qianxing Mo; Chad J Creighton; Susan G Hilsenbeck; Andrew D Leavitt; Michael T Lewis; Stephen T C Wong; Yi Li
Journal:  Cancer Res       Date:  2018-11-06       Impact factor: 12.701

8.  Benchmark studies of UV-vis spectra simulation for cinnamates with UV filter profile.

Authors:  Ricardo D'A Garcia; Vinícius G Maltarollo; Káthia M Honório; Gustavo H G Trossini
Journal:  J Mol Model       Date:  2015-05-21       Impact factor: 1.810

9.  Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin.

Authors:  Yira Bermudez; Steven P Stratton; Clara Curiel-Lewandrowski; James Warneke; Chengcheng Hu; George T Bowden; Sally E Dickinson; Zigang Dong; Ann M Bode; Kathylynn Saboda; Christine A Brooks; Emanuel F Petricoin; Craig A Hurst; David S Alberts; Janine G Einspahr
Journal:  Cancer Prev Res (Phila)       Date:  2015-06-01

10.  Voriconazole N-oxide and its ultraviolet B photoproduct sensitize keratinocytes to ultraviolet A.

Authors:  K Ona; D H Oh
Journal:  Br J Dermatol       Date:  2015-07-20       Impact factor: 9.302
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