Literature DB >> 2229297

Recombinant human activin-A promotes proliferation of human luteinized preovulatory granulosa cells in vitro.

J Rabinovici1, S J Spencer, R B Jaffe.   

Abstract

Ovarian granulosa cells synthesize and secrete activin, a member of the transforming growth factor-beta (TGF-beta) peptide family, during the follicular phase of the menstrual cycle. We examined the growth-promoting activity of human recombinant activin-A on human luteinized preovulatory granulosa cells obtained from women undergoing in vitro fertilization. Activin-A induced proliferation of granulosa cells on day 5 of culture in a dose-dependent manner. Maximal effects were seen at concentrations greater than or equal to 100 ng/mL with an ED50 of 15 ng/mL. We suggest that activin-A is able to modulate growth of ovarian granulosa cells.

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Year:  1990        PMID： 2229297     DOI： 10.1210/jcem-71-5-1396

Source DB:  PubMed          Journal:  J Clin Endocrinol Metab        ISSN： 0021-972X            Impact factor:   5.958


  11 in total

1.  Activin-A as an intraovarian modulator: actions, localization, and regulation of the intact dimer in human ovarian cells.

Authors:  J Rabinovici; S J Spencer; N Doldi; P C Goldsmith; R Schwall; R B Jaffe
Journal:  J Clin Invest       Date:  1992-05       Impact factor: 14.808

Review 2.  Inhibin at 90: from discovery to clinical application, a historical review.

Authors:  Yogeshwar Makanji; Jie Zhu; Rama Mishra; Chris Holmquist; Winifred P S Wong; Neena B Schwartz; Kelly E Mayo; Teresa K Woodruff
Journal:  Endocr Rev       Date:  2014-07-22       Impact factor: 19.871

Review 3.  Activins and Inhibins: Roles in Development, Physiology, and Disease.

Authors:  Maria Namwanje; Chester W Brown
Journal:  Cold Spring Harb Perspect Biol       Date:  2016-07-01       Impact factor: 10.005

4.  Overexpression of activin A in stage IV colorectal cancer.

Authors:  S Wildi; J Kleeff; H Maruyama; C A Maurer; M W Büchler; M Korc
Journal:  Gut       Date:  2001-09       Impact factor: 23.059

5.  Gene expression profiling reveals Cyp26b1 to be an activin regulated gene involved in ovarian granulosa cell proliferation.

Authors:  Jingjing L Kipp; Ann Golebiowski; Guadalupe Rodriguez; Michael Demczuk; Signe M Kilen; Kelly E Mayo
Journal:  Endocrinology       Date:  2010-11-17       Impact factor: 4.736

6.  Expression of inhibin/activin subunits and their receptors and binding proteins in human preimplantation embryos.

Authors:  Z Y He; H C Liu; C A Mele; L Barmat; L L Veeck; O Davis; Z Rosenwaks
Journal:  J Assist Reprod Genet       Date:  1999-02       Impact factor: 3.412

7.  Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors.

Authors:  So-Youn Kim; Katherine Ebbert; Marilia H Cordeiro; Megan M Romero; Kelly A Whelan; Adrian A Suarez; Teresa K Woodruff; Takeshi Kurita
Journal:  Cancer Res       Date:  2016-05-09       Impact factor: 12.701

8.  Expression and localization of inhibin/activin and activin receptors in GH3 cells, a rat pituitary adenocarcinoma cell line.

Authors:  C Ying; Z Zhang; G Huang; S Q Li; S Y Ying
Journal:  J Endocrinol Invest       Date:  1996-01       Impact factor: 4.256

9.  Testicular somatic cells, not gonocytes, are the major source of functional activin A during testis morphogenesis.

Authors:  Denise R Archambeault; Jessica Tomaszewski; Andrew J Childs; Richard A Anderson; Humphrey Hung-Chang Yao
Journal:  Endocrinology       Date:  2011-09-27       Impact factor: 4.736

10.  MicroRNA-181a suppresses mouse granulosa cell proliferation by targeting activin receptor IIA.

Authors:  Qun Zhang; Haixiang Sun; Yue Jiang; Lijun Ding; Shaogen Wu; Ting Fang; Guijun Yan; Yali Hu
Journal:  PLoS One       Date:  2013-03-20       Impact factor: 3.240
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