Literature DB >> 22292751

Introduction: MMPs, ADAMs/ADAMTSs research products to achieve big dream.

Isao Okazaki1, Kazuki Nabeshima.   

Abstract

Matrix metalloproteinases (MMPs) are known to participate in cancer invasion and metastasis. Copious research on MMPs and their inhibitors has promoted the understanding of the mechanisms of cancer invasion and metastasis as well as the development of effective drugs for cancer treatment. This review discusses the classification of MMPs and tissue inhibitors of metalloproteinases (TIMPs) in relation to tumor growth and invasion mechanisms via signal transduction, followed by the possibilities for cancer treatment. The review focuses especially on the development of anti-cancer agents in the field of MMP science.

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Year:  2012        PMID： 22292751     DOI： 10.2174/187152012802650200

Source DB:  PubMed          Journal:  Anticancer Agents Med Chem        ISSN： 1871-5206            Impact factor:   2.505


  8 in total

Review 1.  Recent advances in bone-targeted therapies of metastatic prostate cancer.

Authors:  Xiyun Deng; Guangchun He; Junwen Liu; Feijun Luo; Xiaoning Peng; Shigang Tang; Zhiyong Gao; Qinlu Lin; Jill M Keller; Tao Yang; Evan T Keller
Journal:  Cancer Treat Rev       Date:  2014-04-16       Impact factor: 12.111

2.  HEMO, an ancestral endogenous retroviral envelope protein shed in the blood of pregnant women and expressed in pluripotent stem cells and tumors.

Authors:  Odile Heidmann; Anthony Béguin; Janio Paternina; Raphaël Berthier; Marc Deloger; Olivia Bawa; Thierry Heidmann
Journal:  Proc Natl Acad Sci U S A       Date:  2017-07-24       Impact factor: 11.205

3.  Hepatic progenitor cell expansion in early-stage nonalcoholic steatohepatitis: evidence from immunohistochemistry and immunoelectron microscopy of matrix metalloproteinase-1.

Authors:  Hiroaki Yokomori; Masaya Oda; Wataru Ando; Yutaka Inagaki; Isao Okazaki
Journal:  Med Mol Morphol       Date:  2017-06-02       Impact factor: 2.309

Review 4.  Inhibition of MMPs and ADAM/ADAMTS.

Authors:  Charles J Malemud
Journal:  Biochem Pharmacol       Date:  2019-02-28       Impact factor: 5.858

5.  Novel breast cancer screening: combined expression of miR-21 and MMP-1 in urinary exosomes detects 95% of breast cancer without metastasis.

Authors:  Wataru Ando; Kiyoshi Kikuchi; Takayuki Uematsu; Hiroaki Yokomori; Takashi Takaki; Masaya Sogabe; Yutaka Kohgo; Katsuya Otori; Shigemi Ishikawa; Isao Okazaki
Journal:  Sci Rep       Date:  2019-09-19       Impact factor: 4.379

6.  Fibrogenesis and Carcinogenesis in Nonalcoholic Steatohepatitis (NASH): Involvement of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinase (TIMPs).

Authors:  Isao Okazaki; Takuji Noro; Nobuhiro Tsutsui; Eigoro Yamanouchi; Hajime Kuroda; Masayuki Nakano; Hiroaki Yokomori; Yutaka Inagaki
Journal:  Cancers (Basel)       Date:  2014-06-27       Impact factor: 6.639

7.  MiR-130a-3p attenuates activation and induces apoptosis of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis by directly targeting TGFBR1 and TGFBR2.

Authors:  Yang Wang; Jinghua Du; Xuemin Niu; Na Fu; Rongqi Wang; Yuguo Zhang; Suxian Zhao; Dianxing Sun; Yuemin Nan
Journal:  Cell Death Dis       Date:  2017-05-18       Impact factor: 8.469

8.  Serum matrix metalloproteinase-1 level represents disease activity as opposed to fibrosis in patients with histologically proven nonalcoholic steatohepatitis.

Authors:  Wataru Ando; Hiroaki Yokomori; Nobuhiro Tsutsui; Eigoro Yamanouchi; Yutaka Suzuki; Masaya Oda; Yutaka Inagaki; Katsuya Otori; Isao Okazaki
Journal:  Clin Mol Hepatol       Date:  2017-11-20
  8 in total

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