| Literature DB >> 22290940 |
Yvonne Pfeifer1, Kathrin Schlatterer, Elisabeth Engelmann, Reinhold A Schiller, Hans Reiner Frangenberg, Doris Stiewe, Martin Holfelder, Wolfgang Witte, Patrice Nordmann, Laurent Poirel.
Abstract
Nine carbapenem-resistant Enterobacteriaceae isolates collected from eight patients in five German hospitals were investigated. Six isolates produced the OXA-48 carbapenemase, and three isolates produced OXA-162, which is a point mutant form of OXA-48. Both carbapenemase genes were located on IncL/M-type conjugative plasmids. Insertion sequence IS1999 (truncated or not by IS1R) was located upstream of the bla(OXA-48) and bla(OXA-162) genes in all of the isolates. Pulsed-field gel electrophoresis typing indicated the clonal transmission of an OXA-48-producing Klebsiella pneumoniae strain in two hospitals.Entities:
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Year: 2012 PMID: 22290940 PMCID: PMC3318349 DOI: 10.1128/AAC.05315-11
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191