Literature DB >> 22290936

The crystal structure of human α2-macroglobulin reveals a unique molecular cage.

Aniebrys Marrero1, Stephane Duquerroy, Stefano Trapani, Theodoros Goulas, Tibisay Guevara, Gregers R Andersen, Jorge Navaza, Lars Sottrup-Jensen, F Xavier Gomis-Rüth.   

Abstract

I'm your Venus: the crystal structure of the human methylamine-induced form of α(2)-macroglobulin (α(2)M) shows its large central cavity can accommodate two medium-sized proteinases. Twelve major entrances provide access for small substrates to the cavity and the still-active trapped "prey". The structure unveils the molecular basis of the unique "venus flytrap" mechanism of α(2)M.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22290936     DOI： 10.1002/anie.201108015

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  34 in total

1.  Structure and mechanism of cysteine peptidase gingipain K (Kgp), a major virulence factor of Porphyromonas gingivalis in periodontitis.

Authors:  Iñaki de Diego; Florian Veillard; Maryta N Sztukowska; Tibisay Guevara; Barbara Potempa; Anja Pomowski; James A Huntington; Jan Potempa; F Xavier Gomis-Rüth
Journal:  J Biol Chem       Date:  2014-09-29       Impact factor: 5.157

Review 2.  A simple recipe for the non-expert bioinformaticist for building experimentally-testable hypotheses for proteins with no known homologs.

Authors:  Alexander Zawaira; Youtaro Shibayama
Journal:  J Struct Funct Genomics       Date:  2012-09-07

Review 3.  Methionine oxidation and reduction in proteins.

Authors:  Geumsoo Kim; Stephen J Weiss; Rodney L Levine
Journal:  Biochim Biophys Acta       Date:  2013-05-03

4.  Monoclonal antibodies targeting the disintegrin-like domain of ADAMDEC1 modulates the proteolytic activity and enables quantification of ADAMDEC1 protein in human plasma.

Authors:  Jacob Lund; Anne Mette Elimar Bitsch; Morten Grønbech Rasch; Mari Enoksson; Linda Troeberg; Hideaki Nagase; Mette Loftager; Michael Toft Overgaard; Helle Heibroch Petersen
Journal:  MAbs       Date:  2017-11-29       Impact factor: 5.857

5.  Conformational Differences between Functional Human Immunodeficiency Virus Envelope Glycoprotein Trimers and Stabilized Soluble Trimers.

Authors:  Luis R Castillo-Menendez; Hanh T Nguyen; Joseph Sodroski
Journal:  J Virol       Date:  2019-01-17       Impact factor: 5.103

6.  Structural and functional insights into Escherichia coli α2-macroglobulin endopeptidase snap-trap inhibition.

Authors:  Irene Garcia-Ferrer; Pedro Arêde; Josué Gómez-Blanco; Daniel Luque; Stephane Duquerroy; José R Castón; Theodoros Goulas; F Xavier Gomis-Rüth
Journal:  Proc Natl Acad Sci U S A       Date:  2015-06-22       Impact factor: 11.205

7.  Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin.

Authors:  Amy R Wyatt; Janet R Kumita; Richard W Mifsud; Cherrie A Gooden; Mark R Wilson; Christopher M Dobson
Journal:  Proc Natl Acad Sci U S A       Date:  2014-05-05       Impact factor: 11.205

8.  A2ML1 and otitis media: novel variants, differential expression, and relevant pathways.

Authors:  Eric D Larson; Jose Pedrito M Magno; Matthew J Steritz; Erasmo Gonzalo D V Llanes; Jonathan Cardwell; Melquiadesa Pedro; Tori Bootpetch Roberts; Elisabet Einarsdottir; Rose Anne Q Rosanes; Christopher Greenlee; Rachel Ann P Santos; Ayesha Yousaf; Sven-Olrik Streubel; Aileen Trinidad R Santos; Amanda G Ruiz; Sheryl Mae Lagrana-Villagracia; Dylan Ray; Talitha Karisse L Yarza; Melissa A Scholes; Catherine B Anderson; Anushree Acharya; Samuel P Gubbels; Michael J Bamshad; Stephen P Cass; Nanette R Lee; Rehan S Shaikh; Deborah A Nickerson; Karen L Mohlke; Jeremy D Prager; Teresa Luisa G Cruz; Patricia J Yoon; Generoso T Abes; David A Schwartz; Abner L Chan; Todd M Wine; Eva Maria Cutiongco-de la Paz; Norman Friedman; Katerina Kechris; Juha Kere; Suzanne M Leal; Ivana V Yang; Janak A Patel; Ma Leah C Tantoco; Saima Riazuddin; Kenny H Chan; Petri S Mattila; Maria Rina T Reyes-Quintos; Zubair M Ahmed; Herman A Jenkins; Tasnee Chonmaitree; Lena Hafrén; Charlotte M Chiong; Regie Lyn P Santos-Cortez
Journal:  Hum Mutat       Date:  2019-05-21       Impact factor: 4.878

Review 9.  Domain structure and function of matrix metalloprotease 23 (MMP23): role in potassium channel trafficking.

Authors:  Charles A Galea; Hai M Nguyen; K George Chandy; Brian J Smith; Raymond S Norton
Journal:  Cell Mol Life Sci       Date:  2013-08-03       Impact factor: 9.261

10.  Porphyromonas gingivalis virulence factor gingipain RgpB shows a unique zymogenic mechanism for cysteine peptidases.

Authors:  Iñaki de Diego; Florian T Veillard; Tibisay Guevara; Barbara Potempa; Maryta Sztukowska; Jan Potempa; F Xavier Gomis-Rüth
Journal:  J Biol Chem       Date:  2013-04-04       Impact factor: 5.157
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