OBJECTIVES: We evaluated the susceptibility to fusidic acid, mupirocin and retapamulin of Staphylococcus aureus isolated from nasal and wound swabs. METHODS: The susceptibility to the three agents of S. aureus isolated from general patients in the south of The Netherlands with a skin or soft tissue infection was determined between January 2007 and December 2008. Fusidic acid-resistant isolates were tested for the presence of fusidic acid-resistant genes and compared with the epidemic European fusidic acid-resistant impetigo clone (EEFIC). RESULTS: Fusidic acid resistance was found in 23% of the nasal and 35% of the wound isolates, the majority (~90%) being fusB positive. Most of the isolates belonged to spa type t171 and were isolated from younger patients. One isolate was retapamulin resistant (MIC 8 mg/L) and two were mupirocin resistant. CONCLUSIONS: The EEFIC clone was relatively highly prevalent among the isolated S. aureus. The usefulness of fusidic acid as first-line agent for the treatment of impetigo is questionable. As mupirocin is used in The Netherlands for eradication of methicillin-resistant S. aureus, it is not an alternative; retapamulin might be useful, but further in vivo studies are warranted.
OBJECTIVES: We evaluated the susceptibility to fusidic acid, mupirocin and retapamulin of Staphylococcus aureus isolated from nasal and wound swabs. METHODS: The susceptibility to the three agents of S. aureus isolated from general patients in the south of The Netherlands with a skin or soft tissue infection was determined between January 2007 and December 2008. Fusidic acid-resistant isolates were tested for the presence of fusidic acid-resistant genes and compared with the epidemic European fusidic acid-resistant impetigo clone (EEFIC). RESULTS:Fusidic acid resistance was found in 23% of the nasal and 35% of the wound isolates, the majority (~90%) being fusB positive. Most of the isolates belonged to spa type t171 and were isolated from younger patients. One isolate was retapamulin resistant (MIC 8 mg/L) and two were mupirocin resistant. CONCLUSIONS: The EEFIC clone was relatively highly prevalent among the isolated S. aureus. The usefulness of fusidic acid as first-line agent for the treatment of impetigo is questionable. As mupirocin is used in The Netherlands for eradication of methicillin-resistant S. aureus, it is not an alternative; retapamulin might be useful, but further in vivo studies are warranted.
Authors: Halimah A Boloki; Wasmiyah F Al-Musaileem; Wadha AlFouzan; Tina Verghese; Edet E Udo Journal: Med Princ Pract Date: 2021-07-13 Impact factor: 1.927
Authors: Maike Koningstein; Leon Groen; Kathelijn Geraats-Peters; Suzanne Lutgens; Ariene Rietveld; Petr Jira; Jan Kluytmans; Sabine C de Greeff; Mirjam Hermans; Peter M Schneeberger Journal: Antimicrob Resist Infect Control Date: 2012-11-20 Impact factor: 4.887
Authors: Kevin Kurt; Jean-Philippe Rasigade; Frederic Laurent; Richard V Goering; Helena Žemličková; Ivana Machova; Marc J Struelens; Andreas E Zautner; Silva Holtfreter; Barbara Bröker; Stephen Ritchie; Sin Reaksmey; Direk Limmathurotsakul; Sharon J Peacock; Christiane Cuny; Franziska Layer; Wolfgang Witte; Ulrich Nübel Journal: PLoS One Date: 2013-03-07 Impact factor: 3.240