BACKGROUND: The menstrual cycle influences pain, with symptoms often increasing during the premenstrual (late-luteal) phase. Deficiencies in endogenous inhibition of afferent nociception at the spinal level might contribute to menstrual phase-related changes in pain. PURPOSE: This study assessed whether conditioned pain modulation (CPM) of spinal nociception differs between mid-follicular and late-luteal phases. METHODS: CPM was evoked by a blood pressure cuff affixed to the right forearm and inflated to induce ischemia in 41 healthy women during both menstrual phases. Suprathreshold electric stimuli were delivered to the left sural nerve to evoke pain and the nociceptive flexion reflex (NFR) before, during, and after forearm ischemia. RESULTS: Forearm ischemia produced CPM of electrocutaneous pain and NFR, but inhibition did not differ across mid-follicular and late-luteal phases. CONCLUSIONS: Mechanisms contributing to changes in experimental pain across mid-follicular and late-luteal phases in healthy women are not due to deficits in CPM of spinal nociception.
BACKGROUND: The menstrual cycle influences pain, with symptoms often increasing during the premenstrual (late-luteal) phase. Deficiencies in endogenous inhibition of afferent nociception at the spinal level might contribute to menstrual phase-related changes in pain. PURPOSE: This study assessed whether conditioned pain modulation (CPM) of spinal nociception differs between mid-follicular and late-luteal phases. METHODS: CPM was evoked by a blood pressure cuff affixed to the right forearm and inflated to induce ischemia in 41 healthy women during both menstrual phases. Suprathreshold electric stimuli were delivered to the left sural nerve to evoke pain and the nociceptive flexion reflex (NFR) before, during, and after forearm ischemia. RESULTS: Forearm ischemia produced CPM of electrocutaneous pain and NFR, but inhibition did not differ across mid-follicular and late-luteal phases. CONCLUSIONS: Mechanisms contributing to changes in experimental pain across mid-follicular and late-luteal phases in healthy women are not due to deficits in CPM of spinal nociception.
Authors: Natalie Hellman; Cassandra A Sturycz; Edward W Lannon; Bethany L Kuhn; Yvette M Güereca; Tyler A Toledo; Michael F Payne; Felicitas A Huber; Mara Demuth; Shreela Palit; Joanna O Shadlow; Jamie L Rhudy Journal: J Pain Date: 2019-02-27 Impact factor: 5.820
Authors: Tyler A Toledo; Natalie Hellman; Edward W Lannon; Cassandra A Sturycz; Bethany L Kuhn; Michael F Payne; Shreela Palit; Yvette M Güereca; Joanna O Shadlow; Jamie L Rhudy Journal: Ann Behav Med Date: 2019-11-09
Authors: Monica E Jarrett; Robert J Shulman; Kevin C Cain; Wimon Deechakawan; Lynne T Smith; Philippe Richebé; Margaret Eugenio; Margaret M Heitkemper Journal: Biol Res Nurs Date: 2014-01-24 Impact factor: 2.522
Authors: Shreela Palit; Emily J Bartley; Bethany L Kuhn; Kara L Kerr; Jennifer L DelVentura; Ellen L Terry; Jamie L Rhudy Journal: J Pain Res Date: 2016-02-11 Impact factor: 3.133
Authors: Neil E O'Connell; John Cossar; Louise Marston; Benedict M Wand; David Bunce; G Lorimer Moseley; Lorraine H De Souza Journal: PLoS One Date: 2012-10-17 Impact factor: 3.240