Literature DB >> 2228978

Phenotypic suppression by aminoglycoside antibiotics of mutations blocking erythromycin biosynthesis in Saccharopolyspora erythraea.

M Lewandowska-Skarbek1, C R Hutchinson.   

Abstract

The presence of a sublethal amount of apramycin, the aminoglycoside antibiotic used as a selectable marker in transformations of Saccharopolyspora erythraea with pKC505 and related plasmids, was found to suppress phenotypically the S. erythraea eryB25 and eryB26 mutations blocking erythromycin biosynthesis in this organism, probably by the effect of mistranslation.

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Year:  1990        PMID： 2228978      PMCID： PMC526855          DOI： 10.1128/jb.172.11.6605-6606.1990

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  9 in total

1.  Misreading of RNA codewords induced by aminoglycoside antibiotics.

Authors:  J Davies; L Gorini; B D Davis
Journal:  Mol Pharmacol       Date:  1965-07       Impact factor: 4.436

Review 2.  The Leeuwenhoek lecture, 1987. Towards an understanding of gene switching in Streptomyces, the basis of sporulation and antibiotic production.

Authors:  D A Hopwood
Journal:  Proc R Soc Lond B Biol Sci       Date:  1988-11-22

3.  Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing.

Authors:  S Henikoff
Journal:  Gene       Date:  1984-06       Impact factor: 3.688

4.  A new shuttle cosmid vector, pKC505, for streptomycetes: its use in the cloning of three different spiramycin-resistance genes from a Streptomyces ambofaciens library.

Authors:  M A Richardson; S Kuhstoss; P Solenberg; N A Schaus; R N Rao
Journal:  Gene       Date:  1987       Impact factor: 3.688

5.  The minimal replicon of a streptomycete plasmid produces an ultrahigh level of plasmid DNA.

Authors:  J L Larson; C L Hershberger
Journal:  Plasmid       Date:  1986-05       Impact factor: 3.466

6.  Effects of apramycin, a novel aminoglycoside antibiotic on bacterial protein synthesis.

Authors:  S Perzynski; M Cannon; E Cundliffe; S B Chahwala; J Davies
Journal:  Eur J Biochem       Date:  1979-09

7.  Genetic analysis of erythromycin production in Streptomyces erythreus.

Authors:  J M Weber; C K Wierman; C R Hutchinson
Journal:  J Bacteriol       Date:  1985-10       Impact factor: 3.490

8.  Cloning and expression of daunorubicin biosynthesis genes from Streptomyces peucetius and S. peucetius subsp. caesius.

Authors:  S L Otten; K J Stutzman-Engwall; C R Hutchinson
Journal:  J Bacteriol       Date:  1990-06       Impact factor: 3.490

9.  Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus).

Authors:  J Vara; M Lewandowska-Skarbek; Y G Wang; S Donadio; C R Hutchinson
Journal:  J Bacteriol       Date:  1989-11       Impact factor: 3.490
  9 in total

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