Literature DB >> 22289177

Delivery of Bordetella pertussis adenylate cyclase toxin to target cells via outer membrane vesicles.

Gina M Donato1, Cynthia S Goldsmith, Christopher D Paddock, Joshua C Eby, Mary C Gray, Erik L Hewlett.   

Abstract

Bordetella pertussis adenylate cyclase toxin (ACT) intoxicates cells by producing intracellular cAMP. B. pertussis outer membrane vesicles (OMV) contain ACT on their surface (OMV-ACT), but the properties of OMV-ACT were previously unknown. We found that B. pertussis in the lung from a fatal pertussis case contains OMV, suggesting an involvement in pathogenesis. OMV-ACT and ACT intoxicate cells with and without the toxin's receptor CD11b/CD18. Intoxication by ACT is blocked by antitoxin and anti-CD11b antibodies, but not by cytochalasin-D; in contrast, OMV-ACT is unaffected by either antibody and blocked by cytochalasin-D. Thus OMV-ACT can deliver ACT by processes distinct from those of ACT alone. Copyright Â
© 2012 Federation of European Biochemical Societies. All rights reserved.

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Year:  2012        PMID： 22289177      PMCID： PMC3288663          DOI： 10.1016/j.febslet.2012.01.032

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  28 in total

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Authors:  M C Gray; G M Donato; F R Jones; T Kim; E L Hewlett
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Journal:  J Gen Microbiol       Date:  1970-10

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