Literature DB >> 22288072

An artificial photosensitizer drug network for mitochondria-selective photodynamic therapy.

So Young Park1, Kyung Taek Oh, Young Taik Oh, Nam Muk Oh, Yu Seok Youn, Eun Seong Lee.   

Abstract

We report a new class of photosensitizer drug networks that can home into mitochondria and provide geospatial phototoxicity for tumors. We take advantage of the cleavable chemical network between the photosensitizer drug and poly(ethylene glycol), and find a significant increase in the efficiency of the multimeric drug network in mitochondria uptake and tumor inhibition. This journal is © The Royal Society of Chemistry 2012

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Year:  2012        PMID： 22288072     DOI： 10.1039/c2cc16087k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Multifunctional AIE iridium (III) photosensitizer nanoparticles for two-photon-activated imaging and mitochondria targeting photodynamic therapy.

Authors:  Xuzi Cai; Kang-Nan Wang; Wen Ma; Yuanyuan Yang; Gui Chen; Huijiao Fu; Chunhui Cui; Zhiqiang Yu; Xuefeng Wang
Journal:  J Nanobiotechnology       Date:  2021-08-23       Impact factor: 10.435

2.  Preparation and evaluation of 99mTc-labeled porphyrin complexes prepared using PNP and HYNIC cores: studying the effects of core selection on pharmacokinetics and tumor uptake in a mouse model.

Authors:  Mohini Guleria; Tapas Das; Kusum Vats; Jeyachitra Amirdhanayagam; Anupam Mathur; Haladhar D Sarma; Ashutosh Dash
Journal:  Medchemcomm       Date:  2019-02-22       Impact factor: 3.597

3.  A charge-reversible nanocarrier using PEG-PLL (-g-Ce6, DMA)-PLA for photodynamic therapy.

Authors:  Chaemin Lim; Taehoon Sim; Ngoc Ha Hoang; Chan Eun Jung; Eun Seong Lee; Yu Seok Youn; Kyung Taek Oh
Journal:  Int J Nanomedicine       Date:  2017-08-24

4.  A pillar[5]arene-based [2]rotaxane lights up mitochondria.

Authors:  Guocan Yu; Dan Wu; Yang Li; Zhihua Zhang; Li Shao; Jiong Zhou; Qinglian Hu; Guping Tang; Feihe Huang
Journal:  Chem Sci       Date:  2016-01-21       Impact factor: 9.825
  4 in total

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