Chad Tao1, Li-Xi Yang. 1. Radiobiology Laboratory, California Pacific Medical Center Research Institute, #602, OPR Bldg., 3801 Sacramento St, Ste 316, San Francisco, CA 94118, USA.
Abstract
BACKGROUND: Radiation therapy for primary and secondary liver cancer has been limited due to dose-limiting radiation-associated liver injury. Stereotactic body radiation therapy (SBRT) permits higher dose to tumors while minimizing radiation to uninvolved liver. The purpose of this study was to assess the efficacy and safety of SBRT for treating primary and secondary hepatic neoplasms. MATERIALS AND METHODS: We performed a systematic review of prospective clinical trials published in English. RESULTS: Fifteen studies involving 158 patients with primary tumors and 341 patients with metastases to the liver were included. Treatment was performed in 1-10 fractions to total doses of 18-60 Gy. One year local control and overall survival rates were 50-100% and 33-100% respectively. There were 13 cases of radiation-induced liver disease and 4 grade 5, 6 grade 4, and 69 grade 3 adverse events reported. CONCLUSION: For patients who are unable or unwilling to undergo local therapy, SBRT is safe and efficacious for treating primary and secondary liver cancer.
BACKGROUND: Radiation therapy for primary and secondary liver cancer has been limited due to dose-limiting radiation-associated liver injury. Stereotactic body radiation therapy (SBRT) permits higher dose to tumors while minimizing radiation to uninvolved liver. The purpose of this study was to assess the efficacy and safety of SBRT for treating primary and secondary hepatic neoplasms. MATERIALS AND METHODS: We performed a systematic review of prospective clinical trials published in English. RESULTS: Fifteen studies involving 158 patients with primary tumors and 341 patients with metastases to the liver were included. Treatment was performed in 1-10 fractions to total doses of 18-60 Gy. One year local control and overall survival rates were 50-100% and 33-100% respectively. There were 13 cases of radiation-induced liver disease and 4 grade 5, 6 grade 4, and 69 grade 3 adverse events reported. CONCLUSION: For patients who are unable or unwilling to undergo local therapy, SBRT is safe and efficacious for treating primary and secondary liver cancer.
Authors: Raquibul Hannan; Vitaly Margulis; Stephen G Chun; Nathan Cannon; D W Nathan Kim; Ramzi E Abdulrahman; Arthur Sagalowsky; Ivan Pedrosa; Hak Choy; James Brugarolas; Robert D Timmerman Journal: Cancer Biol Ther Date: 2015 Impact factor: 4.742
Authors: Wensha Yang; Benedick A Fraass; Robert Reznik; Nicholas Nissen; Simon Lo; Laith H Jamil; Kapil Gupta; Howard Sandler; Richard Tuli Journal: Radiat Oncol Date: 2014-01-09 Impact factor: 3.481