Literature DB >> 22287744

The effect of radiotherapy on implant-based breast reconstruction in the setting of skin-sparing mastectomy: clinical series and review of complications.

Kenneth Hughes1, Charles Brown, Victor Perez, Jeannette W C Ting, Warren M Rozen, Iain S Whitaker, Richard Korentager.   

Abstract

BACKGROUND: With the increasing popularity of skin-sparing mastectomy techniques, implant-based breast reconstruction and use of perioperative radiation therapy, there is a growing need to scrutinize the effects they have on breast reconstruction. This study examined the effect of radiation on implant-based breast reconstruction in patients who had skin-sparing or conventional mastectomies in terms of complication, reoperation, and capsular contracture rates. PATIENTS AND METHODS: A retrospective review of 227 implant-based breast reconstructions in 132 mastectomy patients by a single surgeon was undertaken. All cases occurred over a four-year period (2006-2009) at a single institution. Complication, re-operation, and capsular contracture rates were tabulated against immediate and delayed reconstruction, skin-sparing and conventional mastectomy implant-based reconstruction, and irradiated and non-irradiated groups. Chi-square test was performed for statistical analysis.
RESULTS: The overall complication and reoperation rates of 15% and 10% in these 227 reconstructions compare favorably to reviewed series. Delayed reconstruction, skin-sparing mastectomy and irradiation were all associated with a significantly increased rate of re-operation, but not to an increase in complication or capsular contracture rates.
CONCLUSION: The results of this study were more favourable than those of similar studies reported in the current literature, suggesting an increased role for implant-based reconstruction in the setting of adjuvant radiotherapy for patients that undergo skin-sparing mastectomy.

Entities:  

Mesh:

Year:  2012        PMID: 22287744

Source DB:  PubMed          Journal:  Anticancer Res        ISSN: 0250-7005            Impact factor:   2.480


  5 in total

Review 1.  Radiotherapy and breast reconstruction: oncology, cosmesis and complications.

Authors:  Warren M Rozen; Mark W Ashton
Journal:  Gland Surg       Date:  2012-08

2.  Neoadjuvant radiotherapy followed by mastectomy and immediate breast reconstruction : An alternative treatment option for locally advanced breast cancer.

Authors:  Montserrat Pazos; Stefanie Corradini; Darius Dian; Vera von Bodungen; Nina Ditsch; Rachel Wuerstlein; Stephan Schönecker; Nadia Harbeck; Heike Scheithauer; Claus Belka
Journal:  Strahlenther Onkol       Date:  2017-01-25       Impact factor: 3.621

Review 3.  Breast Reconstruction and Radiation Therapy.

Authors:  Johanna H Yun; Roberto Diaz; Amber G Orman
Journal:  Cancer Control       Date:  2018 Jan-Dec       Impact factor: 3.302

4.  Oncologic safety of skin-sparing and nipple-sparing mastectomy: a discussion and review of the literature.

Authors:  Christopher Tokin; Anna Weiss; Jessica Wang-Rodriguez; Sarah L Blair
Journal:  Int J Surg Oncol       Date:  2012-07-17

5.  Porcine acellular dermis-based breast reconstruction: complications and outcomes following adjuvant radiotherapy.

Authors:  Cho Ee Ng; Andrew Pieri; Tarannum Fasih
Journal:  Eur J Plast Surg       Date:  2015-08-02
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.