BACKGROUND: Carcinoma ex pleomorphic adenoma (Ca ex-PA) is defined as a carcinoma arising from a primary (de novo) or recurrent benign pleomorphic adenoma (PA). METHODS: We present a parotid myoepithelial carcinoma ex pleomorphic adenoma in a 38-year-old man with a t(3;8)(p21;q13) as the only chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY). RESULTS: The finding of this translocation in a subset of PA and in the present case suggests a critical role for this event in the malignant transformation of PA. CONCLUSIONS: Collectively, both the cytogenetic and the molecular studies suggest the concept that PA lacking alterations pursue a benign behavior, whereas those with the t(3;8) translocation may progress to carcinoma.
BACKGROUND:Carcinoma ex pleomorphic adenoma (Ca ex-PA) is defined as a carcinoma arising from a primary (de novo) or recurrent benign pleomorphic adenoma (PA). METHODS: We present a parotid myoepithelial carcinoma ex pleomorphic adenoma in a 38-year-old man with a t(3;8)(p21;q13) as the only chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY). RESULTS: The finding of this translocation in a subset of PA and in the present case suggests a critical role for this event in the malignant transformation of PA. CONCLUSIONS: Collectively, both the cytogenetic and the molecular studies suggest the concept that PA lacking alterations pursue a benign behavior, whereas those with the t(3;8) translocation may progress to carcinoma.
Authors: Matthijs H Valstar; Hetty Mast; Ivo Ten Hove; Laura R Moonen; Alfons Jm Balm; Ludi E Smeele; Senada Koljenović; Winand Nm Dinjens; Marie-Louise F van Velthuysen Journal: J Pathol Clin Res Date: 2021-05-07