Literature DB >> 22287307

Irrigation penetration of nasal delivery systems: a cadaver study.

Wesley M Abadie1, Kevin C McMains, Erik Kent Weitzel.   

Abstract

BACKGROUND: To determine the sinus penetration potential of several commercially available irrigation systems in maximally operated sinus cavities; cadaveric study in a tertiary care center.
METHODS: Seven fresh cadaver heads with brains removed were maximally dissected to include a Draf III frontal sinusotomy, wide maxillary antrostomy, and complete sphenoethmoidectomy. Drill-holes (4 mm) were created to allow visualization of the irrigations from within the respective sinus cavity. Seven commercially available irrigation systems were then tested according to manufacturer recommendation, and the data recorded using an ordinal scale for comparison.
RESULTS: Among the 3 atomized particle delivery systems tested, the squeeze atomizer took 1.15 attempts, the pump atomizer took 1.85 attempts, and the mechanized atomizer required 30 seconds of continuous application for intrasinus delivery of aerosol (p = 0.009). Penetration with 4 heavy irrigators showed significant variability depending on the sinus cavity being tested. The NeilMed irrigator showed more consistent penetration than any other tested device (p < 0.01). The other systems tested had varying degrees of efficacy, dependent on sinus cavity irrigated.
CONCLUSION: Delivery of irrigant to maximally operated sinus cavities is variable and highly dependent on the method of nasal delivery. Use of these systems should be tailored appropriately for the desired effect.
Copyright © 2011 American Rhinologic Society-American Academy of Otolaryngic Allergy, LLC.

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Year:  2010        PMID: 22287307     DOI: 10.1002/alr.20002

Source DB:  PubMed          Journal:  Int Forum Allergy Rhinol        ISSN: 2042-6976            Impact factor:   3.858


  8 in total

1.  Surfactant improves irrigant penetration into unoperated sinuses.

Authors:  Joseph W Rohrer; Greg R Dion; Pryor S Brenner; Wesley M Abadie; Kevin C McMains; Roy F Thomas; Erik K Weitzel
Journal:  Am J Rhinol Allergy       Date:  2012 May-Jun       Impact factor: 2.467

Review 2.  Comprehensive review on endonasal endoscopic sinus surgery.

Authors:  Rainer K Weber; Werner Hosemann
Journal:  GMS Curr Top Otorhinolaryngol Head Neck Surg       Date:  2015-12-22

3.  Computational fluid dynamic modeling of nose-to-ceiling head positioning for sphenoid sinus irrigation.

Authors:  John R Craig; James N Palmer; Kai Zhao
Journal:  Int Forum Allergy Rhinol       Date:  2017-01-16       Impact factor: 3.858

4.  Sinus penetration of saline solution irrigation and atomizer in a cadaveric polyp and allergic fungal sinusitis model.

Authors:  Mary Doellman; Philip G Chen; Kevin C McMains; Kathleen M Sarber; Erik K Weitzel
Journal:  Allergy Rhinol (Providence)       Date:  2015-01

5.  Effect of Partial Uncinectomy After Balloon Sinuplasty on Maxillary Sinus Irrigant Penetration: A Cadaveric Study.

Authors:  Jhon F Martinez-Paredes; Selmin Karatayli-Ozgursoy; Valeria Gonzalez; Osarenoma Olomu; Angela M Donaldson
Journal:  OTO Open       Date:  2021-01-27

6.  A novel irrigation device with superior nasal irrigation efficiency to the classic rinse bottle.

Authors:  Dawei Wu; Feifan Chang; Junsheng Hong; Baihan Su; Yongxiang Wei
Journal:  J Otolaryngol Head Neck Surg       Date:  2022-05-03

7.  Efficacy of syringe-irrigation topical therapy and the influence of the middle turbinate in sinus penetration of solutions.

Authors:  Guilherme Henrique Wawginiak; Leonardo Balsalobre; Eduardo Macoto Kosugi; João Paulo Mangussi-Gomes; Raul Ernesto Samaniego; Aldo Cassol Stamm
Journal:  Braz J Otorhinolaryngol       Date:  2016-07-31

8.  Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis.

Authors:  Eduardo Macoto Kosugi; Guilherme Figner Moussalem; Juliana Caminha Simões; Rafael de Paula e Silva Felici de Souza; Vitor Guo Chen; Paulo Saraceni Neto; José Arruda Mendes Neto
Journal:  Braz J Otorhinolaryngol       Date:  2015-09-07
  8 in total

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