One-pot Crabbé homologation-radical cascade cyclisation with memory of chirality.

The tandem Crabbé homologation-radical rearrangement of terminal enediynes leads, in a one-pot procedure, to the enantioselective synthesis of six- and seven-membered ring α-aminoesters bearing a quaternary stereocenter based on the phenomenon of memory of chirality. This journal is © The Royal Society of Chemistry 2012