Literature DB >> 22286193

Current Concepts of the Role of Oxidized LDL Receptors in Atherosclerosis.

Tanu Goyal1, Sona Mitra, Magomed Khaidakov, Xianwei Wang, Sandeep Singla, Zufeng Ding, Shijie Liu, Jawahar L Mehta.   

Abstract

Atherosclerosis is characterized by accumulation of lipids and inflammatory cells in the arterial wall. Oxidized low-density lipoprotein (ox-LDL) plays important role in the genesis and progression of atheromatous plaque. Various scavenger receptors have been recognized in the past two decades that mediate uptake of ox-LDL leading to formation of foam cells. Inhibition of scavenger receptor A and CD36 has been shown to affect progression of atherosclerosis by decreasing foam cell formation. Lectin-type oxidized LDL receptor 1 (LOX-1) participates at various steps involved in the pathogenesis of atherosclerosis, and in experimental studies its blockade has been shown to affect the progression of atherosclerosis at multiple levels. In this review, we summarize the role of ox-LDL and scavenger receptors in the formation of atheroma with emphasis on effects of LOX-1 blockade.

Entities:  

Year:  2012        PMID： 22286193     DOI： 10.1007/s11883-012-0228-1

Source DB:  PubMed          Journal:  Curr Atheroscler Rep        ISSN： 1523-3804            Impact factor:   5.113


  78 in total

1.  Identification of soluble forms of lectin-like oxidized LDL receptor-1.

Authors:  T Murase; N Kume; H Kataoka; M Minami; T Sawamura; T Masaki; T Kita
Journal:  Arterioscler Thromb Vasc Biol       Date:  2000-03       Impact factor: 8.311

2.  Role of macrophage scavenger receptors in diet-induced atherosclerosis in mice.

Authors:  H Sakaguchi; M Takeya; H Suzuki; H Hakamata; T Kodama; S Horiuchi; S Gordon; L J van der Laan; G Kraal; S Ishibashi; N Kitamura; K Takahashi
Journal:  Lab Invest       Date:  1998-04       Impact factor: 5.662

3.  Activation of lectin-like oxidized low-density lipoprotein receptor-1 induces apoptosis in cultured neonatal rat cardiac myocytes.

Authors:  E Iwai-Kanai; K Hasegawa; T Sawamura; M Fujita; T Yanazume; S Toyokuni; S Adachi; Y Kihara; S Sasayama
Journal:  Circulation       Date:  2001-12-11       Impact factor: 29.690

4.  A modification of apolipoprotein B accounts for most of the induction of macrophage growth by oxidized low density lipoprotein.

Authors:  J S Martens; M Lougheed; A Gómez-Muñoz; U P Steinbrecher
Journal:  J Biol Chem       Date:  1999-04-16       Impact factor: 5.157

5.  Activation-dependent surface expression of LOX-1 in human platelets.

Authors:  M Chen; M Kakutani; T Naruko; M Ueda; S Narumiya; T Masaki; T Sawamura
Journal:  Biochem Biophys Res Commun       Date:  2001-03-23       Impact factor: 3.575

Review 6.  Class A scavenger receptors, macrophages, and atherosclerosis.

Authors:  M F Linton; S Fazio
Journal:  Curr Opin Lipidol       Date:  2001-10       Impact factor: 4.776

7.  Fluid shear stress transcriptionally induces lectin-like oxidized LDL receptor-1 in vascular endothelial cells.

Authors:  T Murase; N Kume; R Korenaga; J Ando; T Sawamura; T Masaki; T Kita
Journal:  Circ Res       Date:  1998-08-10       Impact factor: 17.367

8.  Modulation of ADP-induced platelet activation by aspirin and pravastatin: role of lectin-like oxidized low-density lipoprotein receptor-1, nitric oxide, oxidative stress, and inside-out integrin signaling.

Authors:  Muhammad R Marwali; Chang-Ping Hu; Bhavna Mohandas; Abhijit Dandapat; Prabhakar Deonikar; Jiawei Chen; Ian Cawich; Tatsuya Sawamura; Mahendra Kavdia; Jawahar L Mehta
Journal:  J Pharmacol Exp Ther       Date:  2007-05-30       Impact factor: 4.030

9.  Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture.

Authors:  P K Shah; E Falk; J J Badimon; A Fernandez-Ortiz; A Mailhac; G Villareal-Levy; J T Fallon; J Regnstrom; V Fuster
Journal:  Circulation       Date:  1995-09-15       Impact factor: 29.690

10.  Lack of a direct role for macrosialin in oxidized LDL metabolism.

Authors:  Maria C de Beer; Zhenze Zhao; Nancy R Webb; Deneys R van der Westhuyzen; Willem J S de Villiers
Journal:  J Lipid Res       Date:  2003-01-16       Impact factor: 5.922
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  30 in total

1.  Inhibition of the NF-κB pathway by R65 ribozyme gene via adeno-associated virus serotype 9 ameliorated oxidized LDL induced human umbilical vein endothelial cell injury.

Authors:  Hui Zhai; Qing-Jie Chen; Xiao-Ming Gao; Yi-Tong Ma; Bang-Dang Chen; Zi-Xiang Yu; Xiao-Mei Li; Fen Liu; Yang Xiang; Jia Xie; Yi-Ning Yang
Journal:  Int J Clin Exp Pathol       Date:  2015-09-01

Review 2.  LOX-1, a new marker of risk and prognosis in coronary artery disease?

Authors:  Valter Lubrano; Silvana Balzan
Journal:  Mol Cell Biochem       Date:  2013-08-11       Impact factor: 3.396

3.  Oxidized LDL induces FAK-dependent RSK signaling to drive NF-κB activation and VCAM-1 expression.

Authors:  Arif Yurdagul; Florian J Sulzmaier; Xiao L Chen; Christopher B Pattillo; David D Schlaepfer; A Wayne Orr
Journal:  J Cell Sci       Date:  2016-02-18       Impact factor: 5.285

Review 4.  Is it time to screen for the haptoglobin genotype to assess the cardiovascular risk profile and vitamin E therapy responsiveness in patients with diabetes?

Authors:  Moshe Vardi; Andrew P Levy
Journal:  Curr Diab Rep       Date:  2012-06       Impact factor: 4.810

Review 5.  Pathophysiology and Treatments of Oxidative Injury in Ischemic Stroke: Focus on the Phagocytic NADPH Oxidase 2.

Authors:  Federico Carbone; Priscila Camillo Teixeira; Vincent Braunersreuther; François Mach; Nicolas Vuilleumier; Fabrizio Montecucco
Journal:  Antioxid Redox Signal       Date:  2014-04-22       Impact factor: 8.401

6.  Proatherogenic conditions promote autoimmune T helper 17 cell responses in vivo.

Authors:  Hoyong Lim; Young Uk Kim; Hua Sun; Joyce H Lee; Joseph M Reynolds; Shino Hanabuchi; Huaizhu Wu; Ba-Bie Teng; Yeonseok Chung
Journal:  Immunity       Date:  2014-01-09       Impact factor: 31.745

7.  Lipopolysaccharide augments the uptake of oxidized LDL by up-regulating lectin-like oxidized LDL receptor-1 in macrophages.

Authors:  Ekhtear Hossain; Akinobu Ota; Sivasundaram Karnan; Miyuki Takahashi; Shahnewaj B Mannan; Hiroyuki Konishi; Yoshitaka Hosokawa
Journal:  Mol Cell Biochem       Date:  2014-10-28       Impact factor: 3.396

8.  Exendin-4 ameliorates oxidized-LDL-induced inhibition of macrophage migration in vitro via the NF-κB pathway.

Authors:  Ge-fei Ma; Song Chen; Lei Yin; Xiang-dong Gao; Wen-bing Yao
Journal:  Acta Pharmacol Sin       Date:  2013-12-16       Impact factor: 6.150

9.  Inhibitory effects of Dioscin on atherosclerosis and foam cell formation in hyperlipidemia rats.

Authors:  Ping Wang; Li-Ya He; Guo-Dong Shen; Rui-Lin Li; Jun-Li Yang
Journal:  Inflammopharmacology       Date:  2017-04-01       Impact factor: 4.473

10.  Endoplasmic reticulum stress promotes macrophage-derived foam cell formation by up-regulating cluster of differentiation 36 (CD36) expression.

Authors:  Shutong Yao; Cheng Miao; Hua Tian; Hui Sang; Nana Yang; Peng Jiao; Jiju Han; Chuanlong Zong; Shucun Qin
Journal:  J Biol Chem       Date:  2013-12-23       Impact factor: 5.157
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